Thera-SAbDab

DALOTUZUMAB

> Structural Summary

Therapeutic	Dalotuzumab
Target	IGF1R
Heavy Chain	QVQLQESGPGLVKPSETLSLTCTVSGYSITGGYLWNWIRQPPGKGLEWIGYISYDGTNNYKPSLKDRVTISRDTSKNQFSLKLSSVTAADTAVYYCARYGRVFFDYWGQGTLVTVSS
Light Chain	DIVMTQSPLSLPVTPGEPASISCRSSQSIVHSNGNTYLQWYLQKPGQSPQLLIYKVSNRLYGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHVPWTFGQGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (June '19)	Phase-II
Estimated Status (June '19)	Active
Recorded Developmental Technology	na
INN Year Proposed	2009
INN Year Recommended	2010
Companies Involved	Pierre Fabre, Merck & Co
Conditions Approved	na
Conditions Active	Breast cancer, Colorectal cancer, Pancreatic cancer
Conditions Discontinued	Multiple myeloma, Neuroendocrine tumours, Non-small cell lung cancer, Solid tumours
Notes	Jain paper: "Entries in WHO-INN documents (PL102 and RL64) have errors"

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]