Thera-SAbDab

UBLITUXIMAB

> Structural Summary

Therapeutic	Ublituximab
Target	MS4A1
Heavy Chain	QAYLQQSGAELVRPGASVKMSCKASGYTFTSYNMHWVKQTPRQGLEWIGGIYPGNGDTSYNQKFKGKATLTVGKSSSTAYMQLSSLTSEDSAVYFCARYDYNYAMDYWGQGTSVTVSS
Light Chain	QIVLSQSPAILSASPGEKVTMTCRASSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPARFSGSGSGTSYSFTISRVEAEDAATYYCQQWTFNPPTFGGGTRLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (June '19)	Phase-III
Estimated Status (June '19)	Active
Recorded Developmental Technology	EMABling Platform
INN Year Proposed	2010
INN Year Recommended	2011
Companies Involved	LFB Biotechnologies, rEVO Biologics, Johns Hopkins University, TG Therapeutics Inc
Conditions Approved	na
Conditions Active	Chronic lymphocytic leukaemia, Multiple sclerosis, Diffuse large B cell lymphoma, Follicular lymphoma, Mantle-cell lymphoma, Non-Hodgkin's lymphoma, Neuromyelitis optica
Conditions Discontinued	na
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]