| Therapeutic | Urelumab |
| Target | TNFRSF9 |
| Heavy Chain | QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQSPEKGLEWIGEINHGGYVTYNPSLESRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYGPGNYDWYFDLWGRGTLVTVSS |
| Light Chain | EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPALTFGGGTKVEIK |
| 100% seqID Fv Structure | 6mhr%3AAB%3ADE [Fvs: ] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 6mhr%3AAB%3ADE [Fvs: ] |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (August '23) | Phase-II |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | Medarex UltiMAb Mouse |
| INN Year Proposed | 2010 |
| INN Year Recommended | 2011 |
| Companies Involved | Bristol-Myers Squibb%3BNational Cancer Institute %28USA%29%3BOno Pharmaceutical%3BSidney Kimmel Comprehensive Cancer Center at Johns Hopkins%3BUniversity of Chicago%3BMedarex |
| Conditions Approved | na |
| Conditions Active | Non-Hodgkin%27s lymphoma%3BSolid tumours%3BGlioblastoma%3BMultiple myeloma |
| Conditions Discontinued | Colorectal cancer%3BHead and neck cancer%3BMalignant melanoma%3BNon-small cell lung cancer |
| Notes | Jain paper%3A %22VL sequence modified at one position to match patent document %28US7659384%29 and JK germline%22 |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
