Thera-SAbDab

TESIDOLUMAB

> Structural Summary

Therapeutic	Tesidolumab
Target	C5
Heavy Chain	EVQLVQSGAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIGPFFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCARDTPYFDYWGQGTLVTVSS
Light Chain	SYELTQPLSVSVALGQTARITCSGDSIPNYYVYWYQQKPGQAPVLVIYDDSNRPSGIPERFSGSNSGNTATLTISRAQAGDEADYYCQSFDSSLNAEVFGGGTKLTVL
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder2.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Phase-II
Estimated Status (Feb '25)	Active
Recorded Developmental Technology	MorphoSys HuCAL Phage Display;XmAb Engineering Technology
INN Year Proposed	2014
INN Year Recommended	2015
Companies Involved	MorphoSys, Novartis
Conditions Approved	na
Conditions Active	Paroxysmal nocturnal haemoglobinuria
Conditions Discontinued	Choroiditis, Dry age-related macular degeneration, Panuveitis, Thrombotic microangiopathy, Wet age-related macular degeneration
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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