Thera-SAbDab

INEBILIZUMAB

> Structural Summary

Therapeutic	Inebilizumab
Target	CD19
Heavy Chain	EVQLVESGGGLVQPGGSLRLSCAASGFTFSSSWMNWVRQAPGKGLEWVGRIYPGDGDTNYNVKFKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARSGFITTVRDFDYWGQGTLVTVSS
Light Chain	EIVLTQSPDFQSVTPKEKVTITCRASESVDTFGISFMNWFQQKPDQSPKLLIHEASNQGSGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQSKEVPFTFGGGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (August '23)	Approved
Estimated Status (August '23)	Active
Recorded Developmental Technology	POTELLIGENT Technology
INN Year Proposed	2015
INN Year Recommended	2016
Companies Involved	Cellective Therapeutics, MedImmune
Conditions Approved	Neuromyelitis optica
Conditions Active	Autoimmune disorders, Myasthenia gravis, Renal transplant rejection
Conditions Discontinued	B-cell lymphoma, Chronic lymphocytic leukaemia, Diffuse large B-cell lymphoma, Follicular lymphoma, Multiple myeloma, Multiple sclerosis, Systemic scleroderma
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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