Thera-SAbDab

FRUNEVETMAB

> Structural Summary

Therapeutic	Frunevetmab
Target	NGFB
Heavy Chain	QVQLVESGAELVQPGESLRLTCAASGFSLTNNNVNWVRQAPGKGLEWMGGVWAGGATDYNSALKSRLTITRDTSKNTVFLQMHSLQSEDTATYYCARDGGYSSSTLYAMDAWGQGTTVTVSA
Light Chain	DIEMTQSPLSLSVTPGESVSISCRASEDIYNALAWYLQKPGRSPRLLIYNTDTLHTGVPDRFSGSGSGTDFTLKISRVQTEDVGVYFCQHYFHYPRTFGQGTKLELK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Feline Whole mAb
Isotype	G1
Highest Clinical Trial (June '19)	Unknown
Estimated Status (June '19)	Active
Recorded Developmental Technology	PETization Technology
INN Year Proposed	2016
INN Year Recommended	2017
Companies Involved	Nexvet
Conditions Approved	na
Conditions Active	Feline osteoarthritis
Conditions Discontinued	na
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]