Thera-SAbDab

IANALUMAB

> Structural Summary

Therapeutic	Ianalumab
Target	TNFRSF13C
Heavy Chain	QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWGWIRQSPGRGLEWLGRIYYRSKWYNSYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARYQWVPKIGVFDSWGQGTLVTVSS
Light Chain	DIVLTQSPATLSLSPGERATLSCRASQFILPEYLSWYQQKPGQAPRLLIYGSSSRATGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQFYSSPLTFGQGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (June '19)	Phase-II/III
Estimated Status (June '19)	Active
Recorded Developmental Technology	POTELLIGENT Technology
INN Year Proposed	2017
INN Year Recommended	2018
Companies Involved	H. Lee Moffitt Cancer Center and Research Institute, MorphoSys, Novartis
Conditions Approved	na
Conditions Active	Autoimmune hepatitis, Idiopathic pulmonary fibrosis, Multiple sclerosis, Pemphigus vulgaris, Rheumatoid arthritis, Sjogren's syndrome, Systemic lupus erythematosus, Chronic lymphocytic leukaemia
Conditions Discontinued	na
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]