Thera-SAbDab

BEMARITUZUMAB

>   Structural Summary
TherapeuticBemarituzumab
TargetFGFR2
Heavy ChainQVQLVQSGAEVKKPGSSVKVSCKASGYIFTTYNVHWVRQAPGQGLEWIGSIYPDNGDTSYNQNFKGRATITADKSTSTAYMELSSLRSEDTAVYYCARGDFAYWGQGTLVTVSS
Light ChainDIQMTQSPSSLSASVGDRVTITCKASQGVSNDVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQHSTTPYTFGQGTKLEIK
100% seqID Fv StructureNone
99% seqID Fv StructureNone
95-98% seqID Fv Structure7sob [Fvs: GI, HJ, NO], 7soc [Fvs: HL]
>   Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Bemarituzumab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

Sequence identity: 63.28%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 101 102 103 104 105 106 107 108 109 110 111 112 113
bemarituzumab Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y I F T T Y N V H W V R Q A P G Q G L E W I G S I Y P D N G D T S Y N Q N F K G R A T I T A D K S T S T A Y M E L S S L R S E D T A V Y Y C A R G D F - - - - - - - - - - - - - A Y W G Q G T L V T V S S
7soc Q V Q L V Q S G A E V K K P G A S V K V S C K A S G Y P F T S Y G I S W V R Q A P G Q G L E W M G W I S T Y N G N T N Y A Q K F Q G R V T M T T D T S T T T G Y M E L R R L R S D D T A V Y Y C A R D Y T R G A W F G E S L I G G F D N W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
bemarituzumab D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q G V S - N D V A W Y Q Q K P G K A P K L L I Y S A S Y R Y T G V P S R F S G S G S G T D F T F T I S S L Q P E D I A T Y Y C Q Q H S T T P Y T F G Q G T K L E I K
7soc - I V L T Q S P G T L S L S P G E R A T L S C R A S Q T V S S T S L A W Y Q Q K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q H D T S - L T F G G G T K V E - -
Sequence identity: 60.82%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 101 102 103 104 105 106 107 108 109 110 111 112 113
bemarituzumab Q V Q L V Q S G A E V K K P G S S V K V S C K A S G Y I F T T Y N V H W V R Q A P G Q G L E W I G S I Y P D N G D T S Y N Q N F K G R A T I T A D K S T S T A Y M E L S S L R S E D T A V Y Y C A R G D F - - - - - - - - - - - - - A Y W G Q G T L V T V S S
7sob - V Q L V Q S G A E V K K P G A S V K V S C K A S G Y P F T S Y G I S W V R Q A P G Q G L E W M G W I S T Y N G N T N Y A Q K F Q G R V T M T T D T S T T T G Y M E L R R L R S D D T A V Y Y C A R D Y T R G A W F G E S L I G G F D N W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
bemarituzumab D I Q M T Q S P S S L S A S V G D R V T I T C K A S Q G V S - N D V A W Y Q Q K P G K A P K L L I Y S A S Y R Y T G V P S R F S G S G S G T D F T F T I S S L Q P E D I A T Y Y C Q Q H S T T P Y T F G Q G T K L E I K
7sob - - V L T Q S P G T L S L S P G E R A T L S C R A S Q T V S S T S L A W Y Q Q K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q H D T S - L T F G G G T - - - - -
>   Metadata
FormatWhole mAb
IsotypeG1
Highest Clinical Trial (October '21)Phase-III
Estimated Status (October '21)Active
Recorded Developmental TechnologyPOTELLIGENT Technology
INN Year Proposed2017
INN Year Recommended2018
Companies InvolvedFive Prime Therapeutics, ZAI Lab
Conditions Approvedna
Conditions ActiveGastric cancer
Conditions DiscontinuedOesophageal cancer, Solid tumours
Notes

SAbDab papers

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

Dunbar, J., Krawczyk, K. et al. (2014) SAbDab: the Structural Antibody Database. Nucleic Acids Res. 42(D1):D1140-D1146 [link]

Thera-SAbDab paper

Raybould, M.I.J., Marks, C. et al (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Res. 48(D1):D383-D388. [link]

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