Thera-SAbDab

ELIPOVIMAB

>   Structural Summary
TherapeuticElipovimab
TargetHIV-1 gp120
Heavy ChainQMQLQESGPGLVKPSETLSLTCSVSGASISDSYWSWIRRSPGKGLEWIGYVHKSGDTNYNPSLKSRVHLSLDTSKNQVSLSLTGVTAADSGKYYCARTLHGRRIYGIVAFNEWFTYFYMDVWGTGTQVTVSS
Light ChainSDISVAPGETARISCGEKSLGSRAVQWYQHRAGQAPSLIIYNNQDRPSGIPERFSGSPDSRPGTTATLTITSVEAGDEADYYCHIWDSRVPTKWVFGGGTTLTVL
100% seqID Fv StructureNone
99% seqID Fv StructureNone
95-98% seqID Fv Structure4fq1 [Fvs: HL], 4fqc [Fvs: HL], 4jy4 [Fvs: BA]
>   Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Elipovimab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

Sequence identity: 91.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 52B 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
elipovimab Q M Q L Q E S G P G L V K P S E T L S L T C S V S G A S I S D S Y W S W I R R S P G K G L E W I G Y V H - - K S G D T N Y N P S L K S R V H L S L D T S K N Q V S L S L T G V T A A D S G K Y Y C A R T L H G R R I Y G I V A F N E W F T Y F Y M D V W G T G T Q V T V S S
4fq1 Q M Q L Q E S G P G L V K P S E T L S L T C S V S G A S I S D S Y W S W I R R S P G K G L E W I G Y V H K S G - - D T N Y S P S L K S R V N L S L D T S K N Q V S L S L V A A T A A D S G K Y Y C A R T L H G R R I Y G I V A F N E W F T Y F Y M D V W G N G T Q V T V S S

Light chain

Position 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 66A 66B 66C 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
elipovimab S D I S V A P G E T A R I S C G E K S L G S R A V Q W Y Q H R A G Q A P S L I I Y N N Q D R P S G I P E R F S G S P - - - D S R P G T T A T L T I T S V E A G D E A D Y Y C H I W D S R V P T K W V F G G G T T L T V L
4fq1 S D I S V A P G E T A R I S C G E K S L G S R A V Q W Y Q H R A G Q A P S L I I Y N N Q D R P S G I P E R F S G S P D S P F G - - - T T A T L T I T S V E A G D E A D Y Y C H I W D S R V P T K W V F G G G T T L T V L
Sequence identity: 91.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 52B 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
elipovimab Q M Q L Q E S G P G L V K P S E T L S L T C S V S G A S I S D S Y W S W I R R S P G K G L E W I G Y V H - - K S G D T N Y N P S L K S R V H L S L D T S K N Q V S L S L T G V T A A D S G K Y Y C A R T L H G R R I Y G I V A F N E W F T Y F Y M D V W G T G T Q V T V S S
4jy4 Q M Q L Q E S G P G L V K P S E T L S L T C S V S G A S I S D S Y W S W I R R S P G K G L E W I G Y V H K S G - - D T N Y S P S L K S R V N L S L D T S K N Q V S L S L V A A T A A D S G K Y Y C A R T L H G R R I Y G I V A F N E W F T Y F Y M D V W G N G T Q V T V S S

Light chain

Position 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 66A 66B 66C 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
elipovimab S D I S V A P G E T A R I S C G E K S L G S R A V Q W Y Q H R A G Q A P S L I I Y N N Q D R P S G I P E R F S G S P - - - D S R P G T T A T L T I T S V E A G D E A D Y Y C H I W D S R V P T K W V F G G G T T L T V L
4jy4 S D I S V A P G E T A R I S C G E K S L G S R A V Q W Y Q H R A G Q A P S L I I Y N N Q D R P S G I P E R F S G S P D S P F G - - - T T A T L T I T S V E A G D E A D Y Y C H I W D S R V P T K W V F G G G T T L T V L
Sequence identity: 91.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 52B 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 100E 100F 100G 100H 100I 100J 100K 100L 100M 100N 100O 100P 101 102 103 104 105 106 107 108 109 110 111 112 113
elipovimab Q M Q L Q E S G P G L V K P S E T L S L T C S V S G A S I S D S Y W S W I R R S P G K G L E W I G Y V H - - K S G D T N Y N P S L K S R V H L S L D T S K N Q V S L S L T G V T A A D S G K Y Y C A R T L H G R R I Y G I V A F N E W F T Y F Y M D V W G T G T Q V T V S S
4fqc Q M Q L Q E S G P G L V K P S E T L S L T C S V S G A S I S D S Y W S W I R R S P G K G L E W I G Y V H K S G - - D T N Y S P S L K S R V N L S L D T S K N Q V S L S L V A A T A A D S G K Y Y C A R T L H G R R I Y G I V A F N E W F T Y F Y M D V W G N G T Q V T V S S

Light chain

Position 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 66A 66B 66C 67 68 68A 68B 68C 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 95B 95C 96 97 98 99 100 101 102 103 104 105 106 107
elipovimab S D I S V A P G E T A R I S C G E K S L G S R A V Q W Y Q H R A G Q A P S L I I Y N N Q D R P S G I P E R F S G S P - - - D S R P G T T A T L T I T S V E A G D E A D Y Y C H I W D S R V P T K W V F G G G T T L T V L
4fqc S D I S V A P G E T A R I S C G E K S L G S R A V Q W Y Q H R A G Q A P S L I I Y N N Q D R P S G I P E R F S G S P D S P F G - - - T T A T L T I T S V E A G D E A D Y Y C H I W D S R V P T K W V F G G G T T L T V L
>   Metadata
FormatWhole mAb
IsotypeG1
Highest Clinical Trial (June '19)Phase-I
Estimated Status (June '19)Active
Recorded Developmental Technologyna
INN Year Proposed2018
INN Year Recommended2019
Companies InvolvedGilead Sciences
Conditions Approvedna
Conditions ActiveHIV infections
Conditions Discontinuedna
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]