Thera-SAbDab

PEPINEMAB

> Structural Summary

Therapeutic	Pepinemab
Target	SEMA4D
Heavy Chain	QVQLVQSGAEVKKPGSSVKVSCKASGYSFSDYYMHWVRQAPGQGLEWMGQINPTTGGASYNQKFKGKATITVDKSTSTAYMELSSLRSEDTAVYYCARYYYGRHFDVWGQGTTVTVSS
Light Chain	DIVMTQSPDSLAVSLGERATINCKASQSVDYDGDSYMNWYQQKPGQPPKLLIYAASNLESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSNEDPYTFGQGTKLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G4
Highest Clinical Trial (Aug '22)	Phase-II
Estimated Status (Aug '22)	Active
Recorded Developmental Technology	na
INN Year Proposed	2018
INN Year Recommended	2019
Companies Involved	Bristol-Myers Squibb, Children's Oncology Group, Emory University, Merck KGaA, National Cancer Institute (USA), Teva Pharmaceutical Industries, UCLAs Jonsson Comprehensive Cancer Center, Vaccinex
Conditions Approved	na
Conditions Active	Huntington's disease, Non-small cell lung cancer, Osteosarcoma, Solid tumours, Colorectal cancer, Head and neck cancer, Malignant melanoma, Pancreatic cancer
Conditions Discontinued	Multiple sclerosis
Notes

SAbDab papers

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

Dunbar, J., Krawczyk, K. et al. (2014) SAbDab: the Structural Antibody Database. Nucleic Acids Res. 42(D1):D1140-D1146 [link]

Thera-SAbDab paper

Raybould, M.I.J., Marks, C. et al (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Res. 48(D1):D383-D388. [link]

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