Non-identical sequences have been numbered using the Chothia scheme and aligned to Volagidemab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.
Sequence identity: 99.57%
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
52A |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
82A |
82B |
82C |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
100A |
100B |
100C |
100D |
100E |
100F |
100G |
100H |
100I |
100J |
100K |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
108 |
109 |
110 |
111 |
112 |
113 |
volagidemab |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
W |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
4lf3 |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
W |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
volagidemab |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
Q |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |
4lf3 |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
E |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |
Sequence identity: 99.15%
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
52A |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
82A |
82B |
82C |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
100A |
100B |
100C |
100D |
100E |
100F |
100G |
100H |
100I |
100J |
100K |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
108 |
109 |
110 |
111 |
112 |
113 |
volagidemab |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
W |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
5xez |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
Y |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
volagidemab |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
Q |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |
5xez |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
E |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |
Sequence identity: 99.15%
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
52A |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
82A |
82B |
82C |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
100A |
100B |
100C |
100D |
100E |
100F |
100G |
100H |
100I |
100J |
100K |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
108 |
109 |
110 |
111 |
112 |
113 |
volagidemab |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
W |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
5xf1 |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
Y |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
volagidemab |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
Q |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |
5xf1 |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
E |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |
Sequence identity: 99.15%
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
52A |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
82A |
82B |
82C |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
100A |
100B |
100C |
100D |
100E |
100F |
100G |
100H |
100I |
100J |
100K |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
108 |
109 |
110 |
111 |
112 |
113 |
volagidemab |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
W |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
4ers |
Q |
V |
Q |
L |
V |
E |
S |
G |
G |
G |
V |
V |
Q |
P |
G |
R |
S |
L |
R |
L |
S |
C |
A |
A |
S |
G |
F |
T |
F |
S |
S |
Y |
G |
M |
H |
W |
V |
R |
Q |
A |
P |
G |
K |
G |
L |
E |
W |
V |
A |
V |
M |
Y |
Y |
D |
G |
S |
N |
K |
D |
Y |
V |
D |
S |
V |
K |
G |
R |
F |
T |
I |
S |
R |
D |
N |
S |
K |
N |
T |
L |
Y |
L |
Q |
M |
N |
R |
L |
R |
A |
E |
D |
T |
A |
V |
Y |
Y |
C |
A |
R |
E |
K |
D |
H |
Y |
D |
I |
L |
T |
G |
Y |
N |
Y |
Y |
Y |
G |
L |
D |
V |
W |
G |
Q |
G |
T |
T |
V |
T |
V |
S |
S |
Position |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
15 |
16 |
17 |
18 |
19 |
20 |
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
53 |
54 |
55 |
56 |
57 |
58 |
59 |
60 |
61 |
62 |
63 |
64 |
65 |
66 |
67 |
68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
82 |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
101 |
102 |
103 |
104 |
105 |
106 |
107 |
volagidemab |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
Q |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |
4ers |
D |
I |
Q |
M |
T |
Q |
S |
P |
S |
S |
L |
S |
A |
S |
V |
G |
D |
R |
V |
T |
I |
T |
C |
R |
A |
S |
Q |
G |
I |
R |
N |
D |
L |
G |
W |
Y |
Q |
Q |
K |
P |
G |
K |
A |
P |
K |
R |
L |
I |
Y |
A |
A |
S |
S |
L |
E |
S |
G |
V |
P |
S |
R |
F |
S |
G |
S |
G |
S |
G |
T |
E |
F |
T |
L |
T |
I |
S |
S |
V |
Q |
P |
E |
D |
F |
V |
T |
Y |
Y |
C |
L |
Q |
H |
N |
S |
N |
P |
L |
T |
F |
G |
G |
G |
T |
K |
V |
E |
I |
K |