Thera-SAbDab

DOSTARLIMAB

> Structural Summary

Therapeutic	Dostarlimab
Target	PDCD1
Heavy Chain	EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISGGGSYTYYQDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASPYYAMDYWGQGTTVTVSS
Light Chain	DIQLTQSPSFLSAYVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTLHTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQHYSSYPWTFGQGTKLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

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Format	Whole mAb
Isotype	G4
Highest Clinical Trial (June '19)	Phase-III
Estimated Status (June '19)	Active
Recorded Developmental Technology	na
INN Year Proposed	2018
INN Year Recommended	2019
Companies Involved	AnaptysBio, European Network of Gynaecological Oncological Trial Groups, GlaxoSmithKline, TESARO
Conditions Approved	na
Conditions Active	Fallopian tube cancer, Ovarian cancer, Peritoneal cancer, Endometrial cancer, Non-small cell lung cancer, Solid tumours
Conditions Discontinued	na
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]