Thera-SAbDab

LORUKAFUSP

>   Structural Summary
TherapeuticLorukafusp
TargetGanglioside GD2
Heavy ChainEVQLVQSGAEVEKPGASVKISCKASGSSFTGYNMNWVRQNIGKSLEWIGAIDPYYGGTSYNQKFKGRATLTVDKSTSTAYMHLKSLRSEDTAVYYCVSGMEYWGQGTSVTVSS
Light ChainDVVMTQTPLSLPVTPGEPASISCRSSQSLVHRNGNTYLHWYLQKPGQSPKLLIHKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPPLTFGAGTKLELK
100% seqID Fv StructureNone
99% seqID Fv StructureNone
95-98% seqID Fv Structure4trp [Fvs: HL], 4tuj [Fvs: AB, CD], 4tuk [Fvs: HL], 4tul [Fvs: HL], 4tuo [Fvs: AB, CD]
>   Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Lorukafusp.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

Sequence identity: 95.13%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 101 102 103 104 105 106 107 108 109 110 111 112 113
lorukafusp E V Q L V Q S G A E V E K P G A S V K I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S T S T A Y M H L K S L R S E D T A V Y Y C V S G M E Y W G Q G T S V T V S S
4tuj E V Q L L Q S G P E L E K P G A S V M I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S S S T A Y M H L K S L T S E D S A V Y Y C V S G M E Y W G Q G T S V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
lorukafusp D V V M T Q T P L S L P V T P G E P A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
4tuj D V V M T Q T P L S L P V S L G D Q A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
Sequence identity: 95.13%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 101 102 103 104 105 106 107 108 109 110 111 112 113
lorukafusp E V Q L V Q S G A E V E K P G A S V K I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S T S T A Y M H L K S L R S E D T A V Y Y C V S G M E Y W G Q G T S V T V S S
4tuo E V Q L L Q S G P E L E K P G A S V M I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S S S T A Y M H L K S L T S E D S A V Y Y C V S G M E Y W G Q G T S V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
lorukafusp D V V M T Q T P L S L P V T P G E P A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
4tuo D V V M T Q T P L S L P V S L G D Q A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
Sequence identity: 95.13%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 101 102 103 104 105 106 107 108 109 110 111 112 113
lorukafusp E V Q L V Q S G A E V E K P G A S V K I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S T S T A Y M H L K S L R S E D T A V Y Y C V S G M E Y W G Q G T S V T V S S
4trp E V Q L L Q S G P E L E K P G A S V M I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S S S T A Y M H L K S L T S E D S A V Y Y C V S G M E Y W G Q G T S V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
lorukafusp D V V M T Q T P L S L P V T P G E P A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
4trp D V V M T Q T P L S L P V S L G D Q A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
Sequence identity: 95.13%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 101 102 103 104 105 106 107 108 109 110 111 112 113
lorukafusp E V Q L V Q S G A E V E K P G A S V K I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S T S T A Y M H L K S L R S E D T A V Y Y C V S G M E Y W G Q G T S V T V S S
4tuk E V Q L L Q S G P E L E K P G A S V M I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S S S T A Y M H L K S L T S E D S A V Y Y C V S G M E Y W G Q G T S V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
lorukafusp D V V M T Q T P L S L P V T P G E P A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
4tuk D V V M T Q T P L S L P V S L G D Q A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
Sequence identity: 95.13%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 101 102 103 104 105 106 107 108 109 110 111 112 113
lorukafusp E V Q L V Q S G A E V E K P G A S V K I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S T S T A Y M H L K S L R S E D T A V Y Y C V S G M E Y W G Q G T S V T V S S
4tul E V Q L L Q S G P E L E K P G A S V M I S C K A S G S S F T G Y N M N W V R Q N I G K S L E W I G A I D P Y Y G G T S Y N Q K F K G R A T L T V D K S S S T A Y M H L K S L T S E D S A V Y Y C V S G M E Y W G Q G T S V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 30D 30E 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
lorukafusp D V V M T Q T P L S L P V T P G E P A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
4tul D V V M T Q T P L S L P V S L G D Q A S I S C R S S Q S L V H R N G N T Y L H W Y L Q K P G Q S P K L L I H K V S N R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y F C S Q S T H V P P L T F G A G T K L E L K
>   Metadata
FormatWhole mAb Fusion
IsotypeG1
Highest Clinical Trial (June '19)Phase-II
Estimated Status (June '19)Active
Recorded Developmental Technologyna
INN Year Proposed2018
INN Year Recommended2019
Companies InvolvedLexigen Pharmaceuticals, Apeiron Biologics, Merck KGaA, University of Wisconsin-Madison
Conditions Approvedna
Conditions ActiveMalignant melanoma, Neuroblastoma
Conditions Discontinuedna
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]