Thera-SAbDab

URABRELIMAB

> Structural Summary

Therapeutic	Urabrelimab
Target	CD47
Heavy Chain	QVQLQESGPGLVKPSGTLSLTCAVSGVSIRSINWWNWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLNSVTAADTAVYYCARDGGIAVTDYYYYGLDVWGQGTTVTVSS
Light Chain	EIVLTQSPATLSLSPGERATLSCRASESVSSNLAWYQQKPGQAPRLLIYGAFNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSDWFTFGGGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb
Isotype	G4
Highest Clinical Trial (June '19)	Phase-I
Estimated Status (June '19)	Active
Recorded Developmental Technology	na
INN Year Proposed	2019
INN Year Recommended	None
Companies Involved	Surface Oncology
Conditions Approved	na
Conditions Active	Cancers, Multiple myeloma
Conditions Discontinued	na
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]