Thera-SAbDab

PENPULIMAB

>   Structural Summary
TherapeuticPenpulimab
TargetPDCD1
Heavy ChainEVQLVESGGGLVQPGGSLRLSCAASGFAFSSYDMSWVRQAPGKGLDWVATISGGGRYTYYPDSVKGRFTISRDNSKNNLYLQMNSLRAEDTALYYCANRYGEAWFAYWGQGTLVTVSS
Light ChainDIQMTQSPSSMSASVGDRVTFTCRASQDINTYLSWFQQKPGKSPKTLIYRANRLVSGVPSRFSGSGSGQDYTLTISSLQPEDMATYYCLQYDEFPLTFGAGTKLELK
100% seqID Fv StructureNone
99% seqID Fv StructureNone
95-98% seqID Fv StructureNone
>   Metadata
FormatWhole mAb
IsotypeG1
Highest Clinical Trial (June '19)Phase-III
Estimated Status (June '19)Active
Recorded Developmental Technologyna
INN Year Proposed2020
INN Year RecommendedNone
Companies InvolvedAkeso Biopharma, Chia Tai Tianqing Pharmaceutical
Conditions Approvedna
Conditions ActiveNon-small cell lung cancer, Cholangiocarcinoma, Colorectal cancer, Gastric cancer, Head and neck cancer, Liver cancer, Nasopharyngeal cancer, Neuroendocrine tumours, Urogenital cancer, Hodgkin's disease, Solid tumours
Conditions Discontinued
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]