Thera-SAbDab

LORIGERLIMAB

>   Structural Summary
TherapeuticLorigerlimab
Target 1PDCD1
Heavy Chain 1QVQLVQSGAEVKKPGASVKVSCKASGYSFTSYWMNWVRQAPGQGLEWIGVIHPSDSETWLDQKFKDRVTITVDKSTSTAYMELSSLRSEDTAVYYCAREHYGTSPFAYWGQGTLVTVSS
Light Chain 1EIVLTQSPATLSLSPGERATLSCRASESVDNYGMSFMNWFQQKPGQPPKLLIHAASNQGSGVPSRFSGSGSGTDFTLTISSLEPEDTAVYFCQQSKEVPYYFGGGTKVEIK
100% seqID Fv 1 StructureNone
99% seqID Fv 1 StructureNone
95-98% seqID Fv 1 StructureNone
Target 2CTLA4
Heavy Chain 2QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGSNKHYADSVKGRFTVSRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS
Light Chain 2EIVLTQSPGTLSLSPGERATLSCRASQSVSSSFLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDTAVYYCQQYGSSPWTFGQGTKVEIK
100% seqID Fv 2 StructureNone
99% seqID Fv 2 StructureNone
95-98% seqID Fv 2 Structure5tru [Fvs: HL], 5xj3 [Fvs: AB], 6jc2 [Fvs: HL], 6rp8 [Fvs: hl], 7elx [Fvs: HL, hl]
>   Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Lorigerlimab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

Sequence identity: 96.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
lorigerlimab_Fv2 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G S N K H Y A D S V K G R F T V S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S
7elx Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G N N K Y Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
lorigerlimab_Fv2 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V S S S F L A W Y Q Q K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D T A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
7elx E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V G S S Y L A W Y Q Q K P G Q A P R L L I Y G A F S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
Sequence identity: 96.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
lorigerlimab_Fv2 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G S N K H Y A D S V K G R F T V S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S
6rp8 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G N N K Y Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
lorigerlimab_Fv2 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V S S S F L A W Y Q Q K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D T A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
6rp8 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V G S S Y L A W Y Q Q K P G Q A P R L L I Y G A F S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
Sequence identity: 96.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
lorigerlimab_Fv2 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G S N K H Y A D S V K G R F T V S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S
5xj3 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G N N K Y Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
lorigerlimab_Fv2 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V S S S F L A W Y Q Q K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D T A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
5xj3 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V G S S Y L A W Y Q Q K P G Q A P R L L I Y G A F S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
Sequence identity: 96.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
lorigerlimab_Fv2 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G S N K H Y A D S V K G R F T V S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S
5tru Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G N N K Y Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
lorigerlimab_Fv2 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V S S S F L A W Y Q Q K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D T A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
5tru E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V G S S Y L A W Y Q Q K P G Q A P R L L I Y G A F S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
Sequence identity: 96.90%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 101 102 103 104 105 106 107 108 109 110 111 112 113
lorigerlimab_Fv2 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G S N K H Y A D S V K G R F T V S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S
6jc2 Q V Q L V E S G G G V V Q P G R S L R L S C A A S G F T F S S Y T M H W V R Q A P G K G L E W V T F I S Y D G N N K Y Y A D S V K G R F T I S R D N S K N T L Y L Q M N S L R A E D T A I Y Y C A R T G W L G P F D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
lorigerlimab_Fv2 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V S S S F L A W Y Q Q K P G Q A P R L L I Y G A S S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D T A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
6jc2 E I V L T Q S P G T L S L S P G E R A T L S C R A S Q S V G S S Y L A W Y Q Q K P G Q A P R L L I Y G A F S R A T G I P D R F S G S G S G T D F T L T I S R L E P E D F A V Y Y C Q Q Y G S S P W T F G Q G T K V E I K
>   Metadata
FormatBispecific Mixed scFv (scFv-CH2-CH3-scFv)
IsotypeG4;G4
Highest Clinical Trial (October '21)Phase-I
Estimated Status (October '21)Active
Recorded Developmental TechnologyDual-Affinity Re-Targeting Technology
INN Year Proposed2021
INN Year RecommendedNone
Companies InvolvedMacroGenics
Conditions Approvedna
Conditions ActiveSolid tumours
Conditions Discontinuedna
Notes

SAbDab papers

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

Dunbar, J., Krawczyk, K. et al. (2014) SAbDab: the Structural Antibody Database. Nucleic Acids Res. 42(D1):D1140-D1146 [link]

Thera-SAbDab paper

Raybould, M.I.J., Marks, C. et al (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Res. 48(D1):D383-D388. [link]

Our privacy policy