Thera-SAbDab

GIRENTUXIMAB

> Structural Summary

Therapeutic	Girentuximab
Target	CA9
Heavy Chain	DVKLVESGGGLVKLGGSLKLSCAASGFTFSNYYMSWVRQTPEKRLELVAAINSDGGITYYLDTVKGRFTISRDNAKNTLYLQMSSLKSEDTALFYCARHRSGYFSMDYWGQGTSVTVSS
Light Chain	DIVMTQSQRFMSTTVGDRVSITCKASQNVVSAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADFFCQQYSNYPWTFGGGTKLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Whole mAb Radiolabelled
Isotype	G1
Highest Clinical Trial (June '19)	Phase-III
Estimated Status (June '19)	Discontinued
Recorded Developmental Technology	na
INN Year Proposed	2009
INN Year Recommended	2010
Companies Involved	Centocor Inc, Heidelberg Pharma AG
Conditions Approved	na
Conditions Active	na
Conditions Discontinued	Renal cancer
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]