| Therapeutic | Onartuzumab |
| Target | MET |
| Heavy Chain | EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYWLHWVRQAPGKGLEWVGMIDPSNSDTRFNPNFKDRFTISADTSKNTAYLQMNSLRAEDTAVYYCATYRSYVTPLDYWGQGTLVTVSS |
| Light Chain | DIQMTQSPSSLSASVGDRVTITCKSSQSLLYTSSQKNYLAWYQQKPGKAPKLLIYWASTRESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYAYPWTFGQGTKVEIK |
| 100% seqID Fv Structure | 4k3j [Fvs: HL] |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
| 100% seqID Structure | 4k3j [Fvs: HL] |
Follow these links to our prediction tools:
| Format | Fab + di-Fc |
| Isotype | G1 |
| Highest Clinical Trial (Feb '25) | Phase-III |
| Estimated Status (Feb '25) | Discontinued |
| Recorded Developmental Technology | na |
| INN Year Proposed | 2010 |
| INN Year Recommended | 2011 |
| Companies Involved | Chugai Pharmaceutical, Genentech |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Breast cancer, Colorectal cancer, Gastric cancer, Glioblastoma, Liver cancer, Non-small cell lung cancer, Solid tumours |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
