Thera-SAbDab

DEMCIZUMAB

> Structural Summary

Therapeutic	Demcizumab
Target	DLL4
Heavy Chain	QVQLVQSGAEVKKPGASVKISCKASGYSFTAYYIHWVKQAPGQGLEWIGYISSYNGATNYNQKFKGRVTFTTDTSTSTAYMELRSLRSDDTAVYYCARDYDYDVGMDYWGQGTLVTVSS
Light Chain	DIVMTQSPDSLAVSLGERATISCRASESVDNYGISFMKWFQQKPGQPPKLLIYAASNQGSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSKEVPWTFGGGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

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Format	Whole mAb
Isotype	G2
Highest Clinical Trial (June '19)	Phase-I
Estimated Status (June '19)	Discontinued
Recorded Developmental Technology	na
INN Year Proposed	2012
INN Year Recommended	2013
Companies Involved	Celgene Corporation, OncoMed Pharmaceuticals
Conditions Approved	na
Conditions Active	na
Conditions Discontinued	Colorectal cancer, Fallopian tube cancer, Non-small cell lung cancer, Ovarian cancer, Pancreatic cancer, Peritoneal cancer, Solid tumours
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]