Thera-SAbDab

SETOXAXIMAB

> Structural Summary

Therapeutic	Setoxaximab
Target	Shiga Toxin Type 2
Heavy Chain	EVQLQQPGPELEKPGASVKLSCKASGYSFTDYNMNWVKQNNGESLEWIGKIDPYYGGPSYNQKFKDKATLTVDKSSSTAYMQLKSLTSEDSAVYYCTRGGNRDWYFDVWGAGTTLTVSA
Light Chain	DIVLSQSPSSLVVSVGEKVTMSCKSSQSLLYSRNQKNYLAWYQQKPGQSPKVLIYWASTRESGVPDRLTGSGSGTDFTLTISSVKAEDLAVYYCQQYYSYPLTFGAGTKLELK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder2.

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Format	Whole mAb
Isotype	G1
Highest Clinical Trial (Feb '25)	Phase-II
Estimated Status (Feb '25)	Discontinued
Recorded Developmental Technology	na
INN Year Proposed	2012
INN Year Recommended	2013
Companies Involved	Sunol Molecular Corporation, Uniformed Services University of the Health Sciences, BELLUS Health, Taro Pharmaceuticals Inc
Conditions Approved	na
Conditions Active	na
Conditions Discontinued	Haemolytic uraemic syndrome, Shiga-toxigenic Escherichia coli infections
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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