Thera-SAbDab

REMTOLUMAB

>   Structural Summary
TherapeuticRemtolumab
Target 1IL17A
Heavy Chain 1EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVSS
Light Chain 1DIQMTQSPSSLSASVGDRVTITCRASQGIRNYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQRYNRAPYTFGQGTKVEIK
100% seqID Fv 1 Structure4nyl [Fvs: AB, CD, EF, HL], 6cr1 [Fvs: HL]
99% seqID Fv 1 Structure3wd5 [Fvs: HL]
95-98% seqID Fv 1 StructureNone
Target 2TNFA
Heavy Chain 2EVQLVQSGAEVKKPGSSVKVSCKASGGSFGGYGIGWVRQAPGQGLEWMGGITPFFGFADYAQKFQGRVTITADESTTTAYMELSGLTSDDTAVYYCARDPNEFWNGYYSTHDFDSWGQGTTVTVSS
Light Chain 2EIVLTQSPDFQSVTPKEKVTITCRASQDIGSELHWYQQKPDQPPKLLIKYASHSTSGVPSRFSGSGSGTDFTLTINGLEAEDAGTYYCHQTDSLPYTFGPGTKVDIK
100% seqID Fv 2 StructureNone [Fvs: ]
99% seqID Fv 2 StructureNone
95-98% seqID Fv 2 StructureNone
>   Alignments

Non-identical sequences have been numbered using the Chothia scheme and aligned to Remtolumab.
CDR positions are indicated in blue. Mismatching positions are highlighted in orange.

Sequence identity: 99.56%

Heavy chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 100C 100D 101 102 103 104 105 106 107 108 109 110 111 112 113
remtolumab1 E V Q L V E S G G G L V Q P G R S L R L S C A A S G F T F D D Y A M H W V R Q A P G K G L E W V S A I T W N S G H I D Y A D S V E G R F T I S R D N A K N S L Y L Q M N S L R A E D T A V Y Y C A K V S Y L S T A S S L D Y W G Q G T L V T V S S
3wd5 E V Q L V E S G G G L V Q P G R S L R L S C A A S G F T F D D Y A M H W V R Q A P G K G L E W V S A I T W N S G H I D Y A D S V E G R F T I S R D N A K N S L Y L D M N S L R A E D T A V Y Y C A K V S Y L S T A S S L D Y W G Q G T L V T V S S

Light chain

Position 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
remtolumab1 D I Q M T Q S P S S L S A S V G D R V T I T C R A S Q G I R N Y L A W Y Q Q K P G K A P K L L I Y A A S T L Q S G V P S R F S G S G S G T D F T L T I S S L Q P E D V A T Y Y C Q R Y N R A P Y T F G Q G T K V E I K
3wd5 D I Q M T Q S P S S L S A S V G D R V T I T C R A S Q G I R N Y L A W Y Q Q K P G K A P K L L I Y A A S T L Q S G V P S R F S G S G S G T D F T L T I S S L Q P E D V A T Y Y C Q R Y N R A P Y T F G Q G T K V E I K
>   Metadata
FormatBispecific Dual Variable Domain IG
IsotypeG1
Highest Clinical Trial (Jan '20)Phase-II
Estimated Status (Jan '20)Discontinued
Recorded Developmental TechnologyDual Variable Domain Immunoglobulin Technology
INN Year Proposed2016
INN Year Recommended2017
Companies InvolvedAbbott Laboratories, Abbvie
Conditions Approvedna
Conditions Activena
Conditions DiscontinuedPsoriatic arthritis, Rheumatoid arthritis
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]