Thera-SAbDab

LOKIVETMAB

> Structural Summary

Therapeutic	Lokivetmab
Target	IL31
Heavy Chain	EVQLVESGGDLVKPGGSLRLSCVASGFTFSNYGMSWVRQAPGKGLQWVATISYGGSYTYYPDNIKGRFTISRDNAKNTLYLQMNSLRAEDTAMYYCVRGYGYDTMDYWGQGTLVTVSS
Light Chain	EIVMTQSPASLSLSQEEKVTITCKASQSVSFAGTGLMHWYQQKPGQAPKLLIYRASNLEAGVPSRFSGSGSGTDFSFTISSLEPEDVAVYYCQQSREYPWTFGQGTKLEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

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Format	Canine Whole mAb
Isotype	G2
Highest Clinical Trial (June '19)	Approved
Estimated Status (June '19)	NFD
Recorded Developmental Technology	na
INN Year Proposed	2014
INN Year Recommended	2015
Companies Involved	Zoetis
Conditions Approved	Canine atopic dermatitis
Conditions Active	na
Conditions Discontinued	na
Notes

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]