Structure Viewer: 5kov

> Structure details

Crystal Structure of the Human astrovirus 2 Capsid Protein Spike in complex with a Single Chain Variable Fragment of an astrovirus Neutralizing antibody at 3.24-a Resolution

PDB	5kov
Species	MUS MUSCULUS
Method	X-RAY DIFFRACTION
Resolution	3.245Å
Number of Fvs	8
In complex	True
Light chain type	unknown
Has constant region	False

> Fv information

This PDB has 8 Fv(s).

Fv Details
Heavy chain	C
Light chain	C
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	A
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-66.91°
HC1	72.71°
HC2	111.19°
LC1	120.39°
LC2	78.0°
dc	15.01Å

Fv Details
Heavy chain	K
Light chain	K
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	H
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-66.42°
HC1	73.15°
HC2	111.87°
LC1	120.89°
LC2	78.16°
dc	14.97Å

Fv Details
Heavy chain	Q
Light chain	Q
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	N
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-40.73°
HC1	73.28°
HC2	120.5°
LC1	120.82°
LC2	90.53°
dc	16.04Å

Fv Details
Heavy chain	U
Light chain	U
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	T
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-67.76°
HC1	72.23°
HC2	112.36°
LC1	122.91°
LC2	76.59°
dc	15.0Å

Fv Details
Heavy chain	I
Light chain	I
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	G
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-64.49°
HC1	73.39°
HC2	110.17°
LC1	122.5°
LC2	77.76°
dc	14.89Å

Fv Details
Heavy chain	O
Light chain	O
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	M
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-68.28°
HC1	72.74°
HC2	111.73°
LC1	122.27°
LC2	77.72°
dc	15.2Å

Fv Details
Heavy chain	E
Light chain	E
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	B
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-64.44°
HC1	73.43°
HC2	109.94°
LC1	122.76°
LC2	77.51°
dc	14.93Å

Fv Details
Heavy chain	W
Light chain	W
Heavy subgroup	unknown
Light subgroup	unknown
Species	MUS MUSCULUS
In complex?	True
scFv?	True
Has constant domain?	False

Numbered Sequences (chothia)

Heavy chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	82A	82B	82C	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	100A	101	102	103	104	105	106	107	108	109	110	111	112	113
D	V	Q	L	K	Q	S	G	P	G	L	V	Q	P	S	Q	S	L	S	I	T	C	T	V	S	G	F	S	L	I	D	Y	G	V	H	W	V	R	Q	S	P	G	K	G	L	E	W	L	G	V	I	W	T	G	G	S	T	D	Y	N	A	A	F	I	S	R	L	T	I	S	K	D	N	S	K	S	Q	V	F	F	K	M	N	S	L	Q	A	N	D	T	G	I	Y	Y	C	G	R	P	Y	Y	G	N	V	M	D	Y	W	G	Q	G	T	S	V	T	V	S	S

Light chain

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107
D	I	Q	M	T	Q	T	T	S	S	L	S	A	S	L	G	D	R	V	T	I	S	C	R	A	S	Q	D	I	S	N	Y	L	N	W	Y	Q	Q	K	P	D	G	T	V	K	L	L	I	Y	Y	T	S	R	L	H	S	G	V	P	S	R	F	S	G	S	G	S	G	T	D	Y	S	L	T	I	S	N	L	E	Q	E	D	I	A	T	Y	F	C	Q	Q	G	N	T	F	P	P	T	F	G	G	G	T	K	L	E	I	K

Antigen Details
Antigen chains	S
Antigen type	protein
Antigen name	capsid polyprotein vp90
Antigen species	HUMAN ASTROVIRUS-2
Antigen sequence	MGGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTAAAELALVPR

CDR Sequences (chothia definition)
CDRH1	GFSLIDY
CDRH2	WTGGS
CDRH3	PYYGNVMDY
CDRL1	RASQDISNYLN
CDRL2	YTSRLHS
CDRL3	QQGNTFPPT

Orientation Angles (from ABangle)
HL	-64.77°
HC1	73.35°
HC2	114.1°
LC1	129.2°
LC2	81.93°
dc	14.55Å

Additional links and files for download: see help for more details.

Chothia-numbered structure	Download
IMGT-numbered structure	Download
Non-annotated structure from the PDB	Download
Summary file for this antibody	Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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