Structure Viewer: 7stg

>   Structure details

Consequences of Hla Single Chain Trimer Mutations On Peptide Presentation and Binding affinity

PDB7stg
SpeciesLAMA GLAMA
MethodX-RAY DIFFRACTION
Resolution2.7Å
Number of Fvs16
In complexTrue
Light chain typeNA
Has constant regionFalse
>   Structure visualisation
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>   Fv information

This PDB has 16 Fv(s).

>   B/-
Fv Details
Heavy chainB
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   F/-
Fv Details
Heavy chainF
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsE
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   H/-
Fv Details
Heavy chainH
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsG
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   J/-
Fv Details
Heavy chainJ
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsI
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   L/-
Fv Details
Heavy chainL
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsK
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   N/-
Fv Details
Heavy chainN
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsM
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   P/-
Fv Details
Heavy chainP
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsO
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   R/-
Fv Details
Heavy chainR
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsQ
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   T/-
Fv Details
Heavy chainT
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsS
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   V/-
Fv Details
Heavy chainV
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsU
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   X/-
Fv Details
Heavy chainX
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsW
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   Z/-
Fv Details
Heavy chainZ
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsY
Antigen typeprotein
Antigen namerpa-related protein radx peptide,beta-2-microglobulin,mhcclass i antigen chimera
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   b/-
Fv Details
Heavy chainb
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsa
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   d/-
Fv Details
Heavy chaind
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainsc
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   f/-
Fv Details
Heavy chainf
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesLAMA GLAMA
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113
E V K L V E S G G G L V Q P G G S L R L S C A A S G S I F S I N T M G W Y R Q T P G K Q R D L V A D I S S G G S T K Y G D S V K G R F T I S R D N T K N T V Y L Q M N S L K P E D T A V Y Y C Y G L S Y S N D D Y W G Q G T Q V T V S S

Antigen Details
Antigen chainse
Antigen typeprotein
Antigen nameunknown
Antigen speciesHOMO SAPIENS, PONGO PYGMAEUS
Antigen sequenceYPPVPETFGGGGSGGGGSGGGGSIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDMGGGGSGGGGSGGGGSGGGGSGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGCYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMCAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEHHHHHH

CDR Sequences (chothia definition)
CDRH1GSIFSIN
CDRH2SSGGS
CDRH3LSYSNDDY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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