Structure Viewer: 8c7j

>   Structure details

Phage Display Derived Serum albumin Binding Knob Domain Engineered within a Novel Vh Framework 3 Bispecific antibody Format

PDB8c7j
SpeciesCRICETULUS GRISEUS
MethodX-RAY DIFFRACTION
Resolution2Å
Number of Fvs2
In complexFalse
Light chain typeKappa,NA
Has constant regionTrue
>   Structure visualisation
Please note the WebGL plugin needs to be enabled to use PV Viewer.

Display options:














>   Fv information

This PDB has 2 Fv(s).

>   A/-
Fv Details
Heavy chainA
Light chain
Heavy subgroupIGHV3
Light subgroupNA
SpeciesCRICETULUS GRISEUS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 52A 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74
E V Q L V E S G G G L V K P G G S L R L S C A A S G Y T F T D N Y I H W V R Q A P G K G L E W I G Y I N P S S A Y A H Y N E K F K T R F T I S V D K A


CDR Sequences (chothia definition)
CDRH1GYTFTDN
CDRH2NPSSAY
CDRH3

>   -/B
Fv Details
Heavy chain
Light chainB
Heavy subgroupNA
Light subgroupIGKV1
SpeciesCRICETULUS GRISEUS
In complex?False
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107
D I Q M T Q S P S S L S A S V G D R V T I T C R A S E D I Y S G L A W Y Q Q K P G K V P K L L I Y D S S T L H T G V P S R F S G T G S G T D Y T L T I S S L Q P E D V A T Y F C Q Q N Y D F P L T F G Q G T K L E I K


CDR Sequences (chothia definition)
CDRL1RASEDIYSGLA
CDRL2DSSTLHT
CDRL3QQNYDFPLT

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

Our privacy policy