Structure Viewer: 8pnl

>   Structure details

Outward-Open Conformation of a Major Facilitator Superfamily (Mfs) Transporter Mhas2168, a Homologue of Rv1410 From M. Tuberculosis, in complex with an alpaca Nanobody

PDB8pnl
SpeciesVICUGNA PACOS
MethodX-RAY DIFFRACTION
Resolution2.7Å
Number of Fvs2
In complexTrue
Light chain typeNA
Has constant regionFalse
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>   Fv information

This PDB has 2 Fv(s).

>   B/-
Fv Details
Heavy chainB
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesVICUGNA PACOS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
Q G Q L V E S G G G L V Q P G G S L R L S C A D A G S I F N K F P M A W Y R Q A P G K E R E L V A R I S S G G S T N Y A D F V K G R F T I S R D N A K S T L Y L Q M N S L K P E D T A M Y Y C A R I I N S A S N I A Y W G Q G T R V T V S A

Antigen Details
Antigen chainsA
Antigen typeprotein
Antigen nameputative triacylglyceride transporter
Antigen speciesMYCOLICIBACTERIUM HASSIACUM DSM 44199
Antigen sequenceMSAFPQTPNRLIRPRRTSRGIAISAGGLAVLLGALDTYVVVSIVTDIMRDVGIAVNQIQRVTPIITGYLLGYIAAMPLLGRASDRFGRKLLIQISLAGFALGSVITALATNLDVLVAGRVIQGAASGALLPVTLALAADLWATHKRAAVLGGVGAAQELGAVLGPIYGIFVVWLFHHWQAVFWVNVPLALIAMVLIHISLPPRVRTEEPQRVDVTGGLLLALALGLATIGLYNAEPDGKQVLPEYGPPLIIGAVIAAVAFLVWERFARTRLLDPAGVRFRPFLIALLVSLVTGGALMVTLVNVELFGQGVLGLDQDEAVFLLARFLIALPVGALLGGWIATRVGDRAVTAVGLLIAAGGFYLIAQWPADVLESRHDLGFVSLPTLDTDLAIAGFGLGLVIAPLTSAALRVVPAAQHGIASAAVVVARMIGMLIGIAALSAWGLYRFNQYLKEQLAALPPAPADFPGGQMAGQMMRLRTATVQAYVLQYGEIFAITAGLCVFGAVLGLFIAGRREHAEESADAVDGVSNARDRAPSAALEVLFQ

CDR Sequences (chothia definition)
CDRH1GSIFNKF
CDRH2SSGGS
CDRH3IINSASNIAY

>   D/-
Fv Details
Heavy chainD
Light chain
Heavy subgroupIGHV1
Light subgroupNA
SpeciesVICUGNA PACOS
In complex?True
scFv?False
Has constant domain?False

Numbered Sequences (chothia)

Heavy chain

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 82A 82B 82C 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 100A 100B 101 102 103 104 105 106 107 108 109 110 111 112 113
Q G Q L V E S G G G L V Q P G G S L R L S C A D A G S I F N K F P M A W Y R Q A P G K E R E L V A R I S S G G S T N Y A D F V K G R F T I S R D N A K S T L Y L Q M N S L K P E D T A M Y Y C A R I I N S A S N I A Y W G Q G T R V T V S A

Antigen Details
Antigen chainsC
Antigen typeprotein
Antigen nameputative triacylglyceride transporter
Antigen speciesMYCOLICIBACTERIUM HASSIACUM DSM 44199
Antigen sequenceMSAFPQTPNRLIRPRRTSRGIAISAGGLAVLLGALDTYVVVSIVTDIMRDVGIAVNQIQRVTPIITGYLLGYIAAMPLLGRASDRFGRKLLIQISLAGFALGSVITALATNLDVLVAGRVIQGAASGALLPVTLALAADLWATHKRAAVLGGVGAAQELGAVLGPIYGIFVVWLFHHWQAVFWVNVPLALIAMVLIHISLPPRVRTEEPQRVDVTGGLLLALALGLATIGLYNAEPDGKQVLPEYGPPLIIGAVIAAVAFLVWERFARTRLLDPAGVRFRPFLIALLVSLVTGGALMVTLVNVELFGQGVLGLDQDEAVFLLARFLIALPVGALLGGWIATRVGDRAVTAVGLLIAAGGFYLIAQWPADVLESRHDLGFVSLPTLDTDLAIAGFGLGLVIAPLTSAALRVVPAAQHGIASAAVVVARMIGMLIGIAALSAWGLYRFNQYLKEQLAALPPAPADFPGGQMAGQMMRLRTATVQAYVLQYGEIFAITAGLCVFGAVLGLFIAGRREHAEESADAVDGVSNARDRAPSAALEVLFQ

CDR Sequences (chothia definition)
CDRH1GSIFNKF
CDRH2SSGGS
CDRH3IINSASNIAY

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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