Thera-SAbDab

GRUTICIBART

> Structural Summary

Therapeutic	Gruticibart
Target	F11
Heavy Chain	QVQLQESGPGLVKPSETLSITCTVSGFSLTGYGIYWVRQPPGKGLEWLGMIWGDGRTDYNSALKSRVTISKDNSKSQVSLKLSSVTAADTARYYCARDYYGSKDYWGQGTTVTVSS
Light Chain	DIQMTQSPSSLSASVGDRVTITCKASQDVSTAVAWYQQKPGKAPKLLIYLTSYRNTGVPDRFSGSGSGTDFTFTISSLQPEDIAVYYCQQHYKTPYSFGGGTKVEIK
100% seqID Fv Structure	None
99% seqID Fv Structure	None
95-98% seqID Fv Structure	None

There are currently no PDB structures close in sequence to this therapeutic Fv. Click here to build a model with ABodyBuilder.

> SAbPred Links

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Format	Whole mAb
Isotype	G4
Highest Clinical Trial (August '23)	TBC
Estimated Status (August '23)	Active
Recorded Developmental Technology
INN Year Proposed	2023
INN Year Recommended	None
Companies Involved	TBC
Conditions Approved	TBC
Conditions Active	TBC
Conditions Discontinued	TBC
Notes	Genetics: musmus/homosap

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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