| Therapeutic | Narlumosbart |
| Target | TNFSF11/CD254/RANKL/TRANCE/OPGL/ODF |
| Heavy Chain | EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGITGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDPGTTVIMSWFDPWGQGTLVTVSS |
| Light Chain | EIVLTQSPGTLSLSPGERATLSCRASQSVRGRYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVFYCQQYGSSPRTFGQGTKVEIK |
| 100% seqID Fv Structure | None |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (August '23) | Phase-III |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | |
| INN Year Proposed | 2022 |
| INN Year Recommended | None |
| Companies Involved | CSPC Pharmaceutical Group, Shanghai Jinmante Biotechnology |
| Conditions Approved | na |
| Conditions Active | Hypercalcemia of malignancy, Glucocorticoid-induced osteoporosis, Bone metastases from solid tumours |
| Conditions Discontinued | na |
| Notes | 6ghg is technically within 95% ID, but CDRH3 length 7 vs length 15. Same Fv sequence as Denosumab. |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
