| Therapeutic | Retifanlimab |
| Target | PDCD1/CD279/PD1 |
| Heavy Chain | QVQLVQSGAEVKKPGASVKVSCKASGYSFTSYWMNWVRQAPGQGLEWIGVIHPSDSETWLDQKFKDRVTITVDKSTSTAYMELSSLRSEDTAVYYCAREHYGTSPFAYWGQGTLVTVSS |
| Light Chain | EIVLTQSPATLSLSPGERATLSCRASESVDNYGMSFMNWFQQKPGQPPKLLIHAASNQGSGVPSRFSGSGSGTDFTLTISSLEPEDFAVYFCQQSKEVPYTFGGGTKVEIK |
| 100% seqID Fv Structure | None |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (August '23) | Approved |
| Estimated Status (August '23) | Active |
| Recorded Developmental Technology | |
| INN Year Proposed | 2019 |
| INN Year Recommended | 2020 |
| Companies Involved | MacroGenics, Incyte Corporation, ZAI Lab |
| Conditions Approved | Merkel cell carcinoma |
| Conditions Active | Gastic cancers, Oesophageal cancer, Anal cancer, Endometrial cancer, Solid tumours, Colorectal cancer, Acute myeloid leukaemia, Squamous cell cancer, Non-small cell lung cancer, Glioblastoma, Head and neck cancer, Liposarcoma, Pancreatic cancer, Penile cancer, Soft tissue sarcoma |
| Conditions Discontinued | Haematological malignancies |
| Notes | Chimeric: Mouse/Human |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
