| Therapeutic | Rovelizumab |
| Target | ITGAL/CD11A/LFA1A and ITGB2/CD18 |
| Heavy Chain | QVQLVQSGAEVKKPGASVKVSCKASGYTFTNNWMQWVRQAPGQGLEWMGAIFPGDDETRYTQKFRGKATITADTSTSTAYMELSSLRSEDTAVYYCGRGGKLRPFALDYWGQGTLVTVSS |
| Light Chain | DIQMTQSPSSLSASVGDRVTITCRASESVESYGNNFMYWYQQKPGKAPKLLIYLASNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCHQDNEDPPTFGQGTKLEIK |
| 100% seqID Fv Structure | None |
| 99% seqID Fv Structure | None |
| 95-98% seqID Fv Structure | None |
Follow these links to our prediction tools:
| Format | Whole mAb |
| Isotype | G4 |
| Highest Clinical Trial (August '23) | Phase-III |
| Estimated Status (August '23) | Discontinued |
| Recorded Developmental Technology | |
| INN Year Proposed | 1999 |
| INN Year Recommended | 2000 |
| Companies Involved | ICOS Corporation |
| Conditions Approved | na |
| Conditions Active | na |
| Conditions Discontinued | Adult respiratory distress syndrome, Cerebral vasospasm, CNS trauma, Multiple sclerosis, Myocardial infarction, Peripheral arterial occlusive disorders, Shock, Stroke, Vascular restenosis |
| Notes |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]
