Therapeutic | Sonelokimab1 |
Target 1 | IL17A |
Heavy Chain 1 | DVQLVESGGGLVQPGGSLRLSCAASGRTFSSYVVGWFRQAPGKEREFIGAISGSGESIYYAVSEKGRFTISRDNSKNTLYLQMNSLRPEDTAVYYCTADQEFGYLRFGRSEYWGQGTLVTVSS |
Light Chain 1 | na |
100% seqID Fv 1 Structure | None |
99% seqID Fv 1 Structure | None |
95-98% seqID Fv 1 Structure | None |
Target 2 | ALB |
Heavy Chain 2 | EVQLVESGGGLVQPGNSLRLSCAASGFTFSSFGMSWVRQAPGKGLEWVSSISGSGSDTLYADSVKGRFTISRDNAKTTLYLQMNSLRPEDTAVYYCTIGGSLSRSSQGTLVTVSS |
Light Chain 2 | na |
100% seqID Fv 2 Structure | None |
99% seqID Fv 2 Structure | None |
95-98% seqID Fv 2 Structure | None |
Follow these links to our prediction tools:
Format | Trispecific Single Domains (VH-VH'-VH''); Bispecific Entry 1 |
Isotype | na;na |
Highest Clinical Trial (Aug '23) | Phase-II |
Estimated Status (Aug '23) | Active |
Recorded Developmental Technology | |
INN Year Proposed | 2019 |
INN Year Recommended | 2020 |
Companies Involved | Ablynx, Avillion, MoonLake Immunotherapeutics, Merck Serono |
Conditions Approved | na |
Conditions Active | Hidradenitis suppurativa, Psoriasis, Psoriatic arthritis, Ankylosing spondylitis |
Conditions Discontinued | na |
Notes | VH-VH' portion. Joint entry with Sonelokimab2 (trispecific). Humanised: Llama/Human |
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]