Details for 2e7l

Click on any of the tabs below to see the detailed information about the structure.

Structure visualisation

Display options:
Cartoon model
Spacefill model
Wire model
Ball&stick model
Default colouring
Color by B-factor
Color by chain
Color by sec. structure
Color by element
Spin: on off

Structure information

Structure of a High-affinity Mutant of the 2C TCR in complex with Ld/Ql9

Item	Info
PDB	2e7l
Organism	MUS MUSCULUS
Method	X-RAY DIFFRACTION
Resolution	2.5Å
Number of TCRs	2

Paired chains information

This PDB has 2 TCR(s).

C / B

TCR Details:

Item	Info
VB chain	C
VA chain	B
VB IMGT details	TRBV13/TRBJ2
VA IMGT details	TRAV9/TRAJ35
Species	mouse

Antigen Details:

Item	Info
Antigen Chain	P
Antigen Type	Peptide
Antigen Organism	SYNTHETIC CONSTRUCT
Antigen Sequence	QLSPFPFDL
Antigen Length	9

MHC details:

Item	Info
MHC Chain	F \| NA
MHC Type	MH1
MHC Species	mouse
MHC IMGT details	H2-Ld-2

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	A	A	V	T	Q	S	P
B9	B10	B11	B12	B13	B14	B15	B16
R	N	K	V	A	V	T	G
B17	B18	B19	B20	B21	B22	B23	B24
E	K	V	T	L	S	C	N
B25	B26	B27	B28	B29	B37	B38	B39
Q	T	N	N	H	N	N	M
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	D	T	G
B48	B49	B50	B51	B52	B53	B54	B55
H	E	L	R	L	I	Y	Y
B56	B57	B58	B63	B64	B65	B66	B67
S	Y	G	A	G	S	T	E
B68	B69	B70	B71	B72	B74	B75	B76
K	G	D	I	P	D	G	Y
B77	B78	B79	B80	B81	B83	B84	B85
K	A	S	R	P	S	Q	E
B86	B87	B88	B89	B90	B91	B92	B93
N	F	S	L	T	L	E	S
B94	B95	B96	B97	B98	B99	B100	B101
A	T	P	S	Q	T	S	V
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	G	G	G
B114	B115	B116	B117	B118	B119	B120	B121
G	T	L	Y	F	G	A	G
B122	B123	B124	B125	B126	B127
T	R	L	S	V	L

FASTA file

A2	A3	A4	A5	A6	A7	A8	A9
Q	S	V	T	Q	P	D	A
A10	A11	A12	A13	A14	A15	A16	A17
R	V	T	V	S	E	G	A
A18	A19	A20	A21	A22	A23	A24	A25
S	L	Q	L	R	C	K	Y
A26	A27	A28	A29	A36	A37	A38	A39
S	Y	S	A	T	P	Y	L
A40	A41	A42	A43	A44	A45	A46	A47
F	W	Y	V	Q	Y	P	R
A48	A49	A50	A51	A52	A53	A54	A55
Q	G	P	Q	L	L	L	K
A56	A57	A58	A59	A62	A63	A64	A65
Y	Y	S	G	D	P	V	V
A66	A67	A68	A74	A75	A76	A77	A78
Q	G	V	N	G	F	E	A
A79	A80	A81	A82	A83	A84	A85	A86
E	F	S	K	S	N	S	S
A87	A88	A89	A90	A91	A92	A93	A94
F	H	L	R	K	A	S	V
A95	A96	A97	A98	A99	A100	A101	A102
H	R	S	D	S	A	V	Y
A103	A104	A105	A106	A107	A108	A109	A113
F	C	A	V	S	H	Q	G
A114	A115	A116	A117	A118	A119	A120	A121
R	Y	L	T	F	G	S	G
A122	A123	A124	A125	A126	A127	A128
T	K	V	I	V	L	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASGGGGTLY	None	9
CDRB2	SYGAGS	None	6
CDRB1	NNHNN	None	5
CDRA3	AVSHQGRYLT	None	10
CDRA2	YYSGDPVV	None	8
CDRA1	YSATPY	None	6

Orientation and docking angles:

Angle	Value
BC2	104.72°
BC1	71.98°
BA	-59.47°
AC2	80.72°
AC1	125.33°
dc	16.84Å
Docking angle	45.54°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
3e3q_NM	103.85°	71.84°	-59.79°	81.45°	125.08°	16.85Å	1.2
2oi9_CB	104.42°	72.96°	-60.02°	81.13°	125.10°	16.47Å	1.3
3e3q_ED	103.32°	72.06°	-59.90°	80.87°	125.10°	16.80Å	1.5
4x6d_FE	104.85°	71.59°	-60.25°	80.32°	124.25°	16.92Å	1.5
4pj7_HG	105.25°	72.70°	-59.22°	80.59°	124.15°	16.85Å	1.5

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4yfl_HL	109.78°	73.75°	-56.79°	79.59°	122.71°	16.13Å	6.7
1ghf_HL	110.63°	71.68°	-61.52°	81.98°	122.12°	16.05Å	7.2
3bgf_BC	109.96°	71.90°	-55.10°	81.62°	123.51°	15.76Å	7.2
1nma_HL	109.88°	72.48°	-61.03°	81.63°	120.29°	16.40Å	7.5
5te7_HL	110.03°	71.72°	-60.97°	83.32°	120.63°	16.37Å	7.7

D / A

TCR Details:

Item	Info
VB chain	D
VA chain	A
VB IMGT details	TRBV13/TRBJ2
VA IMGT details	TRAV9/TRAJ35
Species	mouse

Antigen Details:

Item	Info
Antigen Chain	Q
Antigen Type	Peptide
Antigen Organism	SYNTHETIC CONSTRUCT
Antigen Sequence	QLSPFPFDL
Antigen Length	9

MHC details:

Item	Info
MHC Chain	E \| NA
MHC Type	MH1
MHC Species	mouse
MHC IMGT details	H2-Ld-2

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	A	A	V	T	Q	S	P
B9	B10	B11	B12	B13	B14	B15	B16
R	N	K	V	A	V	T	G
B17	B18	B19	B20	B21	B22	B23	B24
E	K	V	T	L	S	C	N
B25	B26	B27	B28	B29	B37	B38	B39
Q	T	N	N	H	N	N	M
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	D	T	G
B48	B49	B50	B51	B52	B53	B54	B55
H	E	L	R	L	I	Y	Y
B56	B57	B58	B63	B64	B65	B66	B67
S	Y	G	A	G	S	T	E
B68	B69	B70	B71	B72	B74	B75	B76
K	G	D	I	P	D	G	Y
B77	B78	B79	B80	B81	B83	B84	B85
K	A	S	R	P	S	Q	E
B86	B87	B88	B89	B90	B91	B92	B93
N	F	S	L	T	L	E	S
B94	B95	B96	B97	B98	B99	B100	B101
A	T	P	S	Q	T	S	V
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	G	G	G
B114	B115	B116	B117	B118	B119	B120	B121
G	T	L	Y	F	G	A	G
B122	B123	B124	B125	B126	B127
T	R	L	S	V	L

FASTA file

A2	A3	A4	A5	A6	A7	A8	A9
Q	S	V	T	Q	P	D	A
A10	A11	A12	A13	A14	A15	A16	A17
R	V	T	V	S	E	G	A
A18	A19	A20	A21	A22	A23	A24	A25
S	L	Q	L	R	C	K	Y
A26	A27	A28	A29	A36	A37	A38	A39
S	Y	S	A	T	P	Y	L
A40	A41	A42	A43	A44	A45	A46	A47
F	W	Y	V	Q	Y	P	R
A48	A49	A50	A51	A52	A53	A54	A55
Q	G	P	Q	L	L	L	K
A56	A57	A58	A59	A62	A63	A64	A65
Y	Y	S	G	D	P	V	V
A66	A67	A68	A74	A75	A76	A77	A78
Q	G	V	N	G	F	E	A
A79	A80	A81	A82	A83	A84	A85	A86
E	F	S	K	S	N	S	S
A87	A88	A89	A90	A91	A92	A93	A94
F	H	L	R	K	A	S	V
A95	A96	A97	A98	A99	A100	A101	A102
H	R	S	D	S	A	V	Y
A103	A104	A105	A106	A107	A108	A109	A113
F	C	A	V	S	H	Q	G
A114	A115	A116	A117	A118	A119	A120	A121
R	Y	L	T	F	G	S	G
A122	A123	A124	A125	A126	A127	A128
T	K	V	I	V	L	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASGGGGTLY	None	9
CDRB2	SYGAGS	None	6
CDRB1	NNHNN	None	5
CDRA3	AVSHQGRYLT	None	10
CDRA2	YYSGDPVV	None	8
CDRA1	YSATPY	None	6

Orientation and docking angles:

Angle	Value
BC2	103.46°
BC1	72.58°
BA	-58.01°
AC2	82.08°
AC1	125.57°
dc	16.65Å
Docking angle	44.91°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
6vrm_ED	103.62°	72.56°	-58.21°	82.07°	124.91°	17.13Å	0.9
5jzi_JI	103.64°	71.67°	-57.46°	81.83°	125.91°	16.54Å	1.2
6vth_BA	102.74°	71.64°	-57.94°	81.95°	125.13°	17.18Å	1.4
5yxn_BA	103.61°	72.46°	-58.14°	80.52°	125.75°	16.26Å	1.6
6dfx_JI	101.90°	71.93°	-57.72°	82.26°	125.04°	16.30Å	1.8

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
3mnw_BA	107.15°	71.13°	-53.34°	82.80°	121.51°	16.47Å	7.4
3bgf_BC	109.96°	71.90°	-55.10°	81.62°	123.51°	15.76Å	7.5
4yfl_HL	109.78°	73.75°	-56.79°	79.59°	122.71°	16.13Å	7.6
4ydl_HL	108.56°	70.76°	-54.72°	85.96°	123.49°	15.98Å	7.7
3mnz_BA	108.41°	71.26°	-53.27°	82.05°	121.70°	16.38Å	8.0

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link