Details for 7rm4

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Structure information

Neoantigen P53R175H-Specific TCR 6-11 Binds to P53R175H-HLA-A2

Item	Info
PDB	7rm4
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	3.33Å
Number of TCRs	4

Paired chains information

This PDB has 4 TCR(s).

D / E

TCR Details:

Item	Info
VB chain	D
VA chain	E
VB IMGT details	TRBV11/TRBJ2
VA IMGT details	TRAV6/TRAJ43
Species	human

Antigen Details:

Item	Info
Antigen Chain	C
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	HMTEVVRHC
Antigen Length	9

MHC details:

Item	Info
MHC Chain	A \| B
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*0201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	A	G	V	A	Q	S	P
B9	B10	B11	B12	B13	B14	B15	B16
R	Y	K	I	I	E	K	R
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	V	A	F	W	C	N
B25	B26	B27	B28	B29	B37	B38	B39
P	I	S	G	H	A	T	L
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	Q	Q	I	L	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	G	P	K	L	L	I	Q
B56	B57	B58	B63	B64	B65	B66	B67
F	Q	N	N	G	V	V	D
B68	B69	B70	B71	B72	B73	B74	B75
D	S	Q	L	P	K	D	R
B76	B77	B78	B79	B80	B81	B83	B84
F	S	A	E	R	L	K	G
B85	B86	B87	B88	B89	B90	B91	B92
V	D	S	T	L	K	I	Q
B93	B94	B95	B96	B97	B98	B99	B100
P	A	K	L	E	D	S	A
B101	B102	B103	B104	B105	B106	B107	B108
V	Y	L	C	A	S	S	L
B109	B110	B111	B112	B113	B114	B115	B116
D	P	G	D	T	G	E	L
B117	B118	B119	B120	B121	B122	B123	B124
F	F	G	E	G	S	R	L
B125	B126	B127
T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
S	Q	K	I	E	Q	N	S
A9	A10	A11	A12	A13	A14	A15	A16
E	A	L	N	I	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
K	T	A	T	L	T	C	N
A25	A26	A27	A28	A29	A36	A37	A38
Y	T	N	Y	S	P	A	Y
A39	A40	A41	A42	A43	A44	A45	A46
L	Q	W	Y	R	Q	D	P
A47	A48	A49	A50	A51	A52	A53	A54
G	R	G	P	V	F	L	L
A55	A56	A57	A58	A59	A63	A64	A65
L	I	R	E	N	E	K	E
A66	A67	A68	A74	A75	A76	A77	A78
K	R	K	E	R	L	K	V
A79	A80	A81	A82	A83	A84	A85	A86
T	F	D	T	T	L	K	Q
A87	A88	A89	A90	A91	A92	A93	A94
S	L	F	H	I	T	A	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	A	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A113
L	C	A	L	D	I	Y	P
A114	A115	A116	A117	A118	A119	A120	A121
H	D	M	R	F	G	A	G
A122	A123	A124	A125	A126	A127	A128
T	R	L	T	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSLDPGDTGELF	None	13
CDRB2	FQNNGV	None	6
CDRB1	SGHAT	None	5
CDRA3	ALDIYPHDMR	None	10
CDRA2	IRENEKE	None	7
CDRA1	NYSPAY	None	6

Orientation and docking angles:

Angle	Value
BC2	103.90°
BC1	73.60°
BA	-60.63°
AC2	78.47°
AC1	122.02°
dc	16.02Å
Docking angle	35.58°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
3qh3_DC	103.38°	73.21°	-61.36°	77.35°	122.64°	16.34Å	1.6
8i5c_nm	104.21°	72.97°	-60.48°	78.59°	123.50°	16.53Å	1.7
1g6r_DC	104.52°	72.37°	-60.12°	78.00°	121.40°	16.31Å	1.7
8i5c_xw	104.72°	73.58°	-61.00°	78.00°	123.40°	16.40Å	1.8
5ks9_FE	104.05°	73.02°	-60.27°	79.68°	123.11°	15.88Å	1.8

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
1nma_HL	109.88°	72.48°	-61.03°	81.63°	120.29°	16.40Å	7.1
4yfl_FI	106.92°	71.36°	-64.48°	73.60°	120.95°	15.85Å	7.3
3mo1_BA	109.77°	73.00°	-58.46°	81.03°	119.12°	16.26Å	7.4
4dcq_BA	108.30°	73.42°	-64.76°	82.94°	120.98°	16.23Å	7.6
1nmc_HL	110.09°	71.80°	-64.06°	80.19°	120.88°	16.16Å	7.6

I / J

TCR Details:

Item	Info
VB chain	I
VA chain	J
VB IMGT details	TRBV11/TRBJ2
VA IMGT details	TRAV6/TRAJ43
Species	human

Antigen Details:

Item	Info
Antigen Chain	H
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	HMTEVVRHC
Antigen Length	9

MHC details:

Item	Info
MHC Chain	F \| G
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*0201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	A	G	V	A	Q	S	P
B9	B10	B11	B12	B13	B14	B15	B16
R	Y	K	I	I	E	K	R
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	V	A	F	W	C	N
B25	B26	B27	B28	B29	B37	B38	B39
P	I	S	G	H	A	T	L
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	Q	Q	I	L	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	G	P	K	L	L	I	Q
B56	B57	B58	B63	B64	B65	B66	B67
F	Q	N	N	G	V	V	D
B68	B69	B70	B71	B72	B73	B74	B75
D	S	Q	L	P	K	D	R
B76	B77	B78	B79	B80	B81	B83	B84
F	S	A	E	R	L	K	G
B85	B86	B87	B88	B89	B90	B91	B92
V	D	S	T	L	K	I	Q
B93	B94	B95	B96	B97	B98	B99	B100
P	A	K	L	E	D	S	A
B101	B102	B103	B104	B105	B106	B107	B108
V	Y	L	C	A	S	S	L
B109	B110	B111	B112	B113	B114	B115	B116
D	P	G	D	T	G	E	L
B117	B118	B119	B120	B121	B122	B123	B124
F	F	G	E	G	S	R	L
B125	B126	B127
T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
S	Q	K	I	E	Q	N	S
A9	A10	A11	A12	A13	A14	A15	A16
E	A	L	N	I	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
K	T	A	T	L	T	C	N
A25	A26	A27	A28	A29	A36	A37	A38
Y	T	N	Y	S	P	A	Y
A39	A40	A41	A42	A43	A44	A45	A46
L	Q	W	Y	R	Q	D	P
A47	A48	A49	A50	A51	A52	A53	A54
G	R	G	P	V	F	L	L
A55	A56	A57	A58	A59	A63	A64	A65
L	I	R	E	N	E	K	E
A66	A67	A68	A74	A75	A76	A77	A78
K	R	K	E	R	L	K	V
A79	A80	A81	A82	A83	A84	A85	A86
T	F	D	T	T	L	K	Q
A87	A88	A89	A90	A91	A92	A93	A94
S	L	F	H	I	T	A	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	A	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A113
L	C	A	L	D	I	Y	P
A114	A115	A116	A117	A118	A119	A120	A121
H	D	M	R	F	G	A	G
A122	A123	A124	A125	A126	A127	A128
T	R	L	T	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSLDPGDTGELF	None	13
CDRB2	FQNNGV	None	6
CDRB1	SGHAT	None	5
CDRA3	ALDIYPHDMR	None	10
CDRA2	IRENEKE	None	7
CDRA1	NYSPAY	None	6

Orientation and docking angles:

Angle	Value
BC2	104.11°
BC1	74.07°
BA	-60.18°
AC2	78.44°
AC1	122.39°
dc	16.02Å
Docking angle	35.09°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
8i5c_xw	104.72°	73.58°	-61.00°	78.00°	123.40°	16.40Å	1.6
8i5c_nm	104.21°	72.97°	-60.48°	78.59°	123.50°	16.53Å	1.7
8i5c_dc	104.95°	73.49°	-60.88°	78.46°	123.53°	16.51Å	1.8
5ks9_HG	103.96°	73.13°	-60.30°	79.64°	123.33°	15.94Å	1.8
5ks9_FE	104.05°	73.02°	-60.27°	79.68°	123.11°	15.88Å	1.8

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
1nma_HL	109.88°	72.48°	-61.03°	81.63°	120.29°	16.40Å	7.2
3mo1_BA	109.77°	73.00°	-58.46°	81.03°	119.12°	16.26Å	7.3
4hxb_HL	109.66°	72.24°	-59.19°	82.14°	119.35°	16.41Å	7.6
4yfl_FI	106.92°	71.36°	-64.48°	73.60°	120.95°	15.85Å	7.7
4dcq_BA	108.30°	73.42°	-64.76°	82.94°	120.98°	16.23Å	7.8

N / O

TCR Details:

Item	Info
VB chain	N
VA chain	O
VB IMGT details	TRBV11/TRBJ2
VA IMGT details	TRAV6/TRAJ43
Species	human

Antigen Details:

Item	Info
Antigen Chain	M
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	HMTEVVRHC
Antigen Length	9

MHC details:

Item	Info
MHC Chain	K \| L
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*0201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	A	G	V	A	Q	S	P
B9	B10	B11	B12	B13	B14	B15	B16
R	Y	K	I	I	E	K	R
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	V	A	F	W	C	N
B25	B26	B27	B28	B29	B37	B38	B39
P	I	S	G	H	A	T	L
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	Q	Q	I	L	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	G	P	K	L	L	I	Q
B56	B57	B58	B63	B64	B65	B66	B67
F	Q	N	N	G	V	V	D
B68	B69	B70	B71	B72	B73	B74	B75
D	S	Q	L	P	K	D	R
B76	B77	B78	B79	B80	B81	B83	B84
F	S	A	E	R	L	K	G
B85	B86	B87	B88	B89	B90	B91	B92
V	D	S	T	L	K	I	Q
B93	B94	B95	B96	B97	B98	B99	B100
P	A	K	L	E	D	S	A
B101	B102	B103	B104	B105	B106	B107	B108
V	Y	L	C	A	S	S	L
B109	B110	B111	B112	B113	B114	B115	B116
D	P	G	D	T	G	E	L
B117	B118	B119	B120	B121	B122	B123	B124
F	F	G	E	G	S	R	L
B125	B126	B127
T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
S	Q	K	I	E	Q	N	S
A9	A10	A11	A12	A13	A14	A15	A16
E	A	L	N	I	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
K	T	A	T	L	T	C	N
A25	A26	A27	A28	A29	A36	A37	A38
Y	T	N	Y	S	P	A	Y
A39	A40	A41	A42	A43	A44	A45	A46
L	Q	W	Y	R	Q	D	P
A47	A48	A49	A50	A51	A52	A53	A54
G	R	G	P	V	F	L	L
A55	A56	A57	A58	A59	A63	A64	A65
L	I	R	E	N	E	K	E
A66	A67	A68	A74	A75	A76	A77	A78
K	R	K	E	R	L	K	V
A79	A80	A81	A82	A83	A84	A85	A86
T	F	D	T	T	L	K	Q
A87	A88	A89	A90	A91	A92	A93	A94
S	L	F	H	I	T	A	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	A	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A113
L	C	A	L	D	I	Y	P
A114	A115	A116	A117	A118	A119	A120	A121
H	D	M	R	F	G	A	G
A122	A123	A124	A125	A126	A127	A128
T	R	L	T	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSLDPGDTGELF	None	13
CDRB2	FQNNGV	None	6
CDRB1	SGHAT	None	5
CDRA3	ALDIYPHDMR	None	10
CDRA2	IRENEKE	None	7
CDRA1	NYSPAY	None	6

Orientation and docking angles:

Angle	Value
BC2	105.38°
BC1	74.83°
BA	-61.30°
AC2	76.97°
AC1	121.77°
dc	15.91Å
Docking angle	37.16°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
4grm_DC	105.08°	75.19°	-60.89°	76.33°	122.81°	16.09Å	1.4
4grm_BA	104.75°	74.22°	-61.93°	76.60°	123.01°	16.23Å	1.7
3qh3_BA	105.57°	74.49°	-59.76°	76.29°	122.79°	16.23Å	2.0
5e9d_JI	105.66°	74.72°	-62.56°	77.24°	123.77°	16.37Å	2.4
8i5c_xw	104.72°	73.58°	-61.00°	78.00°	123.40°	16.40Å	2.5

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4yfl_FI	106.92°	71.36°	-64.48°	73.60°	120.95°	15.85Å	6.0
1n4x_HL	110.31°	76.00°	-65.51°	77.43°	122.43°	15.84Å	6.6
2vxu_IM	110.96°	71.68°	-62.78°	78.60°	119.89°	16.17Å	7.0
1nma_HL	109.88°	72.48°	-61.03°	81.63°	120.29°	16.40Å	7.1
1nmc_HL	110.09°	71.80°	-64.06°	80.19°	120.88°	16.16Å	7.1

S / T

TCR Details:

Item	Info
VB chain	S
VA chain	T
VB IMGT details	TRBV11/TRBJ2
VA IMGT details	TRAV6/TRAJ43
Species	human

Antigen Details:

Item	Info
Antigen Chain	R
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	HMTEVVRHC
Antigen Length	9

MHC details:

Item	Info
MHC Chain	P \| Q
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*0201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	A	G	V	A	Q	S	P
B9	B10	B11	B12	B13	B14	B15	B16
R	Y	K	I	I	E	K	R
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	V	A	F	W	C	N
B25	B26	B27	B28	B29	B37	B38	B39
P	I	S	G	H	A	T	L
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	Q	Q	I	L	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	G	P	K	L	L	I	Q
B56	B57	B58	B63	B64	B65	B66	B67
F	Q	N	N	G	V	V	D
B68	B69	B70	B71	B72	B73	B74	B75
D	S	Q	L	P	K	D	R
B76	B77	B78	B79	B80	B81	B83	B84
F	S	A	E	R	L	K	G
B85	B86	B87	B88	B89	B90	B91	B92
V	D	S	T	L	K	I	Q
B93	B94	B95	B96	B97	B98	B99	B100
P	A	K	L	E	D	S	A
B101	B102	B103	B104	B105	B106	B107	B108
V	Y	L	C	A	S	S	L
B109	B110	B111	B112	B113	B114	B115	B116
D	P	G	D	T	G	E	L
B117	B118	B119	B120	B121	B122	B123	B124
F	F	G	E	G	S	R	L
B125	B126	B127
T	V	L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
S	Q	K	I	E	Q	N	S
A9	A10	A11	A12	A13	A14	A15	A16
E	A	L	N	I	Q	E	G
A17	A18	A19	A20	A21	A22	A23	A24
K	T	A	T	L	T	C	N
A25	A26	A27	A28	A29	A36	A37	A38
Y	T	N	Y	S	P	A	Y
A39	A40	A41	A42	A43	A44	A45	A46
L	Q	W	Y	R	Q	D	P
A47	A48	A49	A50	A51	A52	A53	A54
G	R	G	P	V	F	L	L
A55	A56	A57	A58	A59	A63	A64	A65
L	I	R	E	N	E	K	E
A66	A67	A68	A74	A75	A76	A77	A78
K	R	K	E	R	L	K	V
A79	A80	A81	A82	A83	A84	A85	A86
T	F	D	T	T	L	K	Q
A87	A88	A89	A90	A91	A92	A93	A94
S	L	F	H	I	T	A	S
A95	A96	A97	A98	A99	A100	A101	A102
Q	P	A	D	S	A	T	Y
A103	A104	A105	A106	A107	A108	A109	A113
L	C	A	L	D	I	Y	P
A114	A115	A116	A117	A118	A119	A120	A121
H	D	M	R	F	G	A	G
A122	A123	A124	A125	A126	A127	A128
T	R	L	T	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSLDPGDTGELF	None	13
CDRB2	FQNNGV	None	6
CDRB1	SGHAT	None	5
CDRA3	ALDIYPHDMR	None	10
CDRA2	IRENEKE	None	7
CDRA1	NYSPAY	None	6

Orientation and docking angles:

Angle	Value
BC2	104.23°
BC1	72.87°
BA	-60.50°
AC2	77.34°
AC1	122.23°
dc	16.36Å
Docking angle	35.18°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
3qh3_DC	103.38°	73.21°	-61.36°	77.35°	122.64°	16.34Å	1.3
1g6r_DC	104.52°	72.37°	-60.12°	78.00°	121.40°	16.31Å	1.3
1mwa_BA	104.83°	72.25°	-59.58°	77.40°	122.34°	16.58Å	1.3
6uz1_JI	103.24°	72.55°	-60.29°	76.44°	122.02°	16.41Å	1.4
8i5c_xw	104.72°	73.58°	-61.00°	78.00°	123.40°	16.40Å	1.7

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4yfl_FI	106.92°	71.36°	-64.48°	73.60°	120.95°	15.85Å	6.4
1nma_HL	109.88°	72.48°	-61.03°	81.63°	120.29°	16.40Å	7.4
1nmc_HL	110.09°	71.80°	-64.06°	80.19°	120.88°	16.16Å	7.6
3mo1_BA	109.77°	73.00°	-58.46°	81.03°	119.12°	16.26Å	7.6
2vxu_IM	110.96°	71.68°	-62.78°	78.60°	119.89°	16.17Å	7.7

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Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link