| Reference title | Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection |
| Reference authors | Akiba,H.;Fujita,J.;Ise,T. et al. |
| Reference URL | https://opig.stats.ox.ac.uk/webapps/newsabdab/sabdab/structureviewer/?pdb=8hlb |
| Heavy chain | QVQLKESGPGLVAPSQSLSITCTVSGFSLTVYGVNWVRQPPGKGLEWLGMIWGDGSTAYNSALKSRLTITKDNSKTQVFLKMNSLQTDDTARYYCARDGRRYALDYWGQGTSVTVSS |
| Light chain | DIVLTQSPTSLAVSLGQRATISCRASESVDSYGDSFLHWYQQKPGQPPILLIYRASNLDSGIPARFSGSGSRTDFTLTINPVEADDVATYYCQQSNEDPYTFGGGTKLEIK |
| Heavy chain definition | Cryo-Em Structure Of Biparatopic Antibody Bp109-92 In Complex With Tnfr2 |
| Light chain definition | Cryo-Em Structure Of Biparatopic Antibody Bp109-92 In Complex With Tnfr2 |
| Organism | homo sapiens |
| Targets mentioned | TNFRSF1B; TNF-R-II; p75; TNFR80; TNFR2; TNFBR; TNF-R75; CD120b |
| Update date | 04-OCT-2023 |
Brennan Abanades et al. “The Patent and Literature Antibody Database (PLAbDab):
an evolving reference set of functionally diverse, literature-annotated antibody sequences and structures”. In: Nucleic Acids Research, Volume 52, Issue D1, 5 January 2024, Pages D545-D551 [ link]
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Header image credit: David Goodsell
