| Reference title | FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma |
| Reference authors | Zhang,G.;Guo,C.;Wang,Y. et al. |
| Reference URL | https://opig.stats.ox.ac.uk/webapps/newsabdab/sabdab/structureviewer/?pdb=8il3 |
| Heavy chain | QVQLVQSGSELKKPGASVKVSCKASGYTFTDYNVHWIRQAPGQGLEWIGYFYPRNGATHYNQKFTGRAVLSADTSVSTAYLQISSLKAEDTAVYFCARGETPGTFPYWGQGTLVTVSS |
| Light chain | DIVLTQSPASLAVSPGQRATITCRASESVDNFGITFMHWYQQKPGQPPKLLIYRASNLESGVPARFSGSGSRTDFTLTINPVEANDTANYYCQQSSKDPRTFGQGTKLEIK |
| Heavy chain definition | Cryo-Em Structure Of Cd38 In Complex With Ftl004 |
| Light chain definition | Cryo-Em Structure Of Cd38 In Complex With Ftl004 |
| Organism | homo sapiens |
| Targets mentioned | apoptotic; cADPR1; CD38 |
| Update date | 29-MAR-2023 |
Brennan Abanades et al. “The Patent and Literature Antibody Database (PLAbDab):
an evolving reference set of functionally diverse, literature-annotated antibody sequences and structures”. In: Nucleic Acids Research, Volume 52, Issue D1, 5 January 2024, Pages D545-D551 [ link]
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Header image credit: David Goodsell
