Pox-AbDab is a database of sequences, structures and functions of antibodies and nanobodies that bind to and/or neutralise orthopoxviruses that are pathogenic to humans. Pox-AbDab is maintained as a public database for the purpose of pandemic preparedness.
Explanations and analysis of the database contents can be found in our paper. Please consider citing it if you are making use of our database in your research.
If you have recently released a publication with orthopoxvirus-binding antibodies, please let us know by emailing opig [at] stats.ox.ac.uk.
Pox-AbDab currently contains 308 unique entries (last updated: August 22, 2025).
Please note that the data contained within Pox-AbDab is available under a CC BY 4.0 licence.
To view all entries, leave all search fields as 'All' and click 'Search'.
The reference table below assists searches for orthologous proteins by highlighting orthopoxvirus-specific nomenclature. All proteins listed below appear in Pox-AbDab at least once labeled in this way. To obtain all antibodies binding to orthologous proteins, we advise that you run separate searches on each of the related antigens listed here.
Each orthopoxvirus strain is listed here alongside the GenBank ID of its genetic sequence.
| VACV Copenhagen (OP868847.1) | CPXV BR (AF482758.2) | CPXV Grishak (X94355.2) | MPXV Zaire79 (HM172544.1) | VARV Bangladesh-1975 (DQ437581.1) | VARV India-1953 (DQ441428.1) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Protein | Protein | Identity | Protein | Identity | Protein | Identity | Protein | Identity | Protein | Identity |
| A27 | A29 | 99% | ||||||||
| A33 | A35 | 91% | A36 | 90% | ||||||
| B5 | CPXV199 | 87% | B6 | 92% | B6 | 93% | B7 | 87% | ||
| D8 | E8 | 90% | ||||||||
| H3 | J3 | 98% | H3 | 88% | I3 | 94% | ||||
| L1 | M1 | 98% | M1 | 99% | ||||||
Henriette L. Capel, Eric Ji Da Wang, Benjamin H. Williams, Charlotte M. Deane, Matthew I. J. Raybould (2025); Pox-AbDab: the Orthopoxvirus Antibody Database. bioRxiv 2025.08.22.671799; doi: 10.1101/2025.08.22.671799
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Header image credit: NIAID
