ABodyBuilder2

Machine Learning based antibody Fv modelling

This web application is designed for small-scale structural modelling. If you would like to perform large-scale analyses, please contact: opig@stats.ox.ac.uk

• ABodyBuilder2 can be used to produce models of the antibody Fv regions.
• Submit heavy and light chain sequences to the forms below to generate a model.
• The sequence and final models will be renumbered with ANARCI
• An example of the output produced by ABodyBuilder2 can be seen here.

The paper describing ABodyBuilder2 can be found here:

Abanades, B., Wong, W.K., Boyles, F., Georges, G., Bujotzek, A. & Deane, C.M. (2023) ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins Communications biology, 6:575

Heavy chain sequence:

load example

QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSA

Light chain sequence:

load example

QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKHELK

Job name:

amulirafusp

IMGT Kabat Chothia Martin

Model