ANARCI

Antigen receptor Numbering And Receptor ClassificatIon.

• ANARCI is a tool for numbering amino-acid sequences of antibody and T-cell receptor variable domains.
• Use the form below to identify domains and annotate them with either the IMGT, Chothia, Kabat, Martin (Enhanced Chothia) or AHo numbering scheme.
• TCR sequences can only be numbered with IMGT or AHo schemes.
• ANARCI aligns a given sequence to a database of Hidden Markov Models that describe the germline sequences of antibody and TCR domain types.
• The most significant alignment predicts the domain type and species (*) of the input sequence.

The ANARCI Python package is freely available on Github.

For a full description of the pipeline, or if you use this software, please refer to: Dunbar J and Deane CM. ANARCI: Antigen receptor numbering and receptor classification. Bioinformatics (2016)

(*) NB: The ANARCI web application restricts germline species to human and mouse to ensure numbering remains consistent over time. If you wish to use other species' germlnies, you can do this using the ANARCI Python package available on GitHub

Submit single sequence:

load example

QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKHELK

or upload multiple sequences as a fasta file:

Choose a numbering scheme:

IMGT Kabat Chothia Martin AHo

Choose an output format:

Comma separated value (csv) file (horizontal format) Plain text (txt) file (vertical format)

Restrict to immunoglobulin domains only
Annotate