The relative orientation between the variable domains (Vβ and Vα) can be represented by six metrics, known as the
TRangles. These values act as a quantitative description of the TCR's antigen-binding site. These values are similar to the
ABangle
parameters that are used for antibodies. To calculate the similarity in orientations, we calculate the ABangle distance of the
six ABangle/TRangle parameters between two TCRs or an antibody and a TCR. If the distance is less than 10, two structures are considered similar.
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BA | the torsion angle between B1 and A1 |
BC1 | the bend angle between B1 and C |
BC2 | the bend angle between B2 and C |
AC1 | the bend angle between A1 and C |
AC2 | the bend angle between A2 and C |
dc | the length of C |
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