Structure summary for 2f54

Detailed entry information.

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Details for 2f54

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Structure information

Directed Evolution of Human T Cell Receptor Cdr2 Residues By Phage Display Dramatically Enhances affinity For Cognate Peptide-MHC without increasing apparent Cross-Reactivity

ItemInfo
PDB2f54
OrganismHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.7Å
Number of TCRs2
Paired chains information

This PDB has 2 TCR(s).

E / D
TCR Details:
ItemInfo
VB chainE
VA chainD
VB IMGT detailsTRBV6/TRBJ2
VA IMGT detailsTRAV21/TRAJ6
Specieshuman
Antigen Details:
ItemInfo
Antigen ChainC
Antigen TypePeptide
Antigen OrganismSYNTHETIC CONSTRUCT
Antigen SequenceSLLMWITQC
Antigen Length9
MHC details:
ItemInfo
MHC ChainA | B
MHC TypeMH1
MHC Specieshuman
MHC IMGT detailsHLA-A*0201
Numbered sequence
Chain typeChain IDFASTA/Annotation fileIMGT numbered sequence (Framework/CDR)
VBE FASTA file
B3 B4 B5 B6 B7 B8 B9 B10
G V T Q T P K F
B11 B12 B13 B14 B15 B16 B17 B18
Q V L K T G Q S
B19 B20 B21 B22 B23 B24 B25 B26
M T L Q C A Q D
B27 B28 B29 B37 B38 B39 B40 B41
M N H E Y M S W
B42 B43 B44 B45 B46 B47 B48 B49
Y R Q D P G M G
B50 B51 B52 B53 B54 B55 B56 B57
L R L I H Y S V
B58 B63 B64 B65 B66 B67 B68 B69
G A G I T D Q G
B70 B71 B72 B74 B75 B76 B77 B78
E V P N G Y N V
B79 B80 B81 B83 B84 B85 B86 B87
S R S T T E D F
B88 B89 B90 B91 B92 B93 B94 B95
P L R L L S A A
B96 B97 B98 B99 B100 B101 B102 B103
P S Q T S V Y F
B104 B105 B106 B107 B108 B109 B110 B112
C A S S Y V G N
B113 B114 B115 B116 B117 B118 B119 B120
T G E L F F G E
B121 B122 B123 B124 B125 B126 B127
G S R L T V L
VAD FASTA file
A1 A2 A3 A4 A5 A6 A7 A8
K Q Q V T Q I P
A9 A10 A11 A12 A13 A14 A15 A16
A A L S V P E G
A17 A18 A19 A20 A21 A22 A23 A24
E N L V L N C S
A25 A26 A27 A28 A29 A36 A37 A38
F T D S A I Y N
A39 A40 A41 A42 A43 A44 A45 A46
L Q W F R Q D P
A47 A48 A49 A50 A51 A52 A53 A54
G G K L T S L L
A55 A56 A57 A58 A59 A63 A64 A65
L I Q S S Q R E
A66 A67 A68 A74 A75 A76 A77 A78
Q T S G R L N A
A79 A80 A81 A82 A83 A84 A85 A86
S L D K S A G S
A87 A88 A89 A90 A91 A92 A93 A94
S T L Y I A A S
A95 A96 A97 A98 A99 A100 A101 A102
Q P G D S A T Y
A103 A104 A105 A106 A107 A108 A109 A110
L C A V R P T S
A111 A112 A113 A114 A115 A116 A117 A118
G G S Y I P T F
A119 A120 A121 A122 A123 A124 A125 A126
G R G T S L I V
A127 A128
H P
CDR Sequences:
LoopSequencePredicted canonical formCDR Length
CDRB3ASSYVGNTGELFNone12
CDRB2SVGAGINone6
CDRB1MNHEYNone5
CDRA3AVRPTSGGSYIPTNone13
CDRA2IQSSQRENone7
CDRA1DSAIYNNone6
Orientation and docking angles:
AngleValue
BC298.01°
BC169.94°
BA-45.79°
AC289.54°
AC1123.82°
dc17.23Å
Docking angle66.93°
TCRs with similar orientations:
TCR PDBBC2BC1BAAC2AC1dcTRangle Distance
2f53_ED 98.66° 70.55° -45.38° 89.09° 123.08° 17.05Å 1.3
6q3s_ED 98.41° 70.06° -44.57° 89.80° 124.11° 17.21Å 1.3
2bnq_ED 99.08° 70.19° -46.99° 87.94° 123.48° 17.00Å 2.3
2p5e_ED 99.36° 69.92° -44.56° 87.86° 123.35° 17.00Å 2.5
2p5w_ED 99.57° 70.45° -44.08° 88.69° 123.18° 17.26Å 2.6

L / K
TCR Details:
ItemInfo
VB chainL
VA chainK
VB IMGT detailsTRBV6/TRBJ2
VA IMGT detailsTRAV21/TRAJ6
Specieshuman
Antigen Details:
ItemInfo
Antigen ChainH
Antigen TypePeptide
Antigen OrganismSYNTHETIC CONSTRUCT
Antigen SequenceSLLMWITQC
Antigen Length9
MHC details:
ItemInfo
MHC ChainF | G
MHC TypeMH1
MHC Specieshuman
MHC IMGT detailsHLA-A*0201
Numbered sequence
Chain typeChain IDFASTA/Annotation fileIMGT numbered sequence (Framework/CDR)
VBL FASTA file
B3 B4 B5 B6 B7 B8 B9 B10
G V T Q T P K F
B11 B12 B13 B14 B15 B16 B17 B18
Q V L K T G Q S
B19 B20 B21 B22 B23 B24 B25 B26
M T L Q C A Q D
B27 B28 B29 B37 B38 B39 B40 B41
M N H E Y M S W
B42 B43 B44 B45 B46 B47 B48 B49
Y R Q D P G M G
B50 B51 B52 B53 B54 B55 B56 B57
L R L I H Y S V
B58 B63 B64 B65 B66 B67 B68 B69
G A G I T D Q G
B70 B71 B72 B74 B75 B76 B77 B78
E V P N G Y N V
B79 B80 B81 B83 B84 B85 B86 B87
S R S T T E D F
B88 B89 B90 B91 B92 B93 B94 B95
P L R L L S A A
B96 B97 B98 B99 B100 B101 B102 B103
P S Q T S V Y F
B104 B105 B106 B107 B108 B109 B110 B112
C A S S Y V G N
B113 B114 B115 B116 B117 B118 B119 B120
T G E L F F G E
B121 B122 B123 B124 B125 B126 B127
G S R L T V L
VAK FASTA file
A1 A2 A3 A4 A5 A6 A7 A8
K Q Q V T Q I P
A9 A10 A11 A12 A13 A14 A15 A16
A A L S V P E G
A17 A18 A19 A20 A21 A22 A23 A24
E N L V L N C S
A25 A26 A27 A28 A29 A36 A37 A38
F T D S A I Y N
A39 A40 A41 A42 A43 A44 A45 A46
L Q W F R Q D P
A47 A48 A49 A50 A51 A52 A53 A54
G G K L T S L L
A55 A56 A57 A58 A59 A63 A64 A65
L I Q S S Q R E
A66 A67 A68 A74 A75 A76 A77 A78
Q T S G R L N A
A79 A80 A81 A82 A83 A84 A85 A86
S L D K S A G S
A87 A88 A89 A90 A91 A92 A93 A94
S T L Y I A A S
A95 A96 A97 A98 A99 A100 A101 A102
Q P G D S A T Y
A103 A104 A105 A106 A107 A108 A109 A110
L C A V R P T S
A111 A112 A113 A114 A115 A116 A117 A118
G G S Y I P T F
A119 A120 A121 A122 A123 A124 A125 A126
G R G T S L I V
A127 A128
H P
CDR Sequences:
LoopSequencePredicted canonical formCDR Length
CDRB3ASSYVGNTGELFNone12
CDRB2SVGAGINone6
CDRB1MNHEYNone5
CDRA3AVRPTSGGSYIPTNone13
CDRA2IQSSQRENone7
CDRA1DSAIYNNone6
Orientation and docking angles:
AngleValue
BC297.77°
BC170.00°
BA-49.95°
AC286.54°
AC1123.25°
dc16.87Å
Docking angle71.20°
TCRs with similar orientations:
TCR PDBBC2BC1BAAC2AC1dcTRangle Distance
2bnr_ED 99.46° 70.52° -47.45° 87.20° 123.24° 16.92Å 3.1
3axl_HG 99.51° 70.17° -48.53° 88.24° 124.46° 17.11Å 3.1
3axl_BA 99.15° 70.16° -47.82° 88.22° 124.38° 17.25Å 3.3
2bnq_ED 99.08° 70.19° -46.99° 87.94° 123.48° 17.00Å 3.5
5euo_HG 99.86° 68.43° -49.00° 82.87° 122.72° 17.43Å 4.7

Available downloads

Additional links and files for download: see help for more details.

ItemLink
IMGT-numbered structureLink
Non-annotated structure from the PDBLink
Summary file for this TCRLink
Link in the PDBLink