Details for 2ian

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Structure information

Structural Basis For Recognition of Mutant Self By a Tumor-Specific, MHC Class Ii-Restricted TCR

Item	Info
PDB	2ian
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.8Å
Number of TCRs	4

Paired chains information

This PDB has 4 TCR(s).

E / D

TCR Details:

Item	Info
VB chain	E
VA chain	D
VB IMGT details	TRBV6/TRBJ1
VA IMGT details	TRAV22/TRAJ54
Species	human

Antigen Details:

Item	Info
Antigen Chain	C
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	GELIGTLNAAKVPAD
Antigen Length	15

MHC details:

Item	Info
MHC Chain	A \| B
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DRA0101 / HLA-DRB10101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
N	A	G	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
K	F	R	I	L	K	I	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	M	T	L	Q	C	T
B25	B26	B27	B28	B29	B37	B38	B39
Q	D	M	N	H	N	Y	M
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	D	P	G
B48	B49	B50	B51	B52	B53	B54	B55
M	G	L	K	L	I	Y	Y
B56	B57	B58	B63	B64	B65	B66	B67
S	V	G	A	G	I	T	D
B68	B69	B70	B71	B72	B74	B75	B76
K	G	E	V	P	N	G	Y
B77	B78	B79	B80	B81	B83	B84	B85
N	V	S	R	S	T	T	E
B86	B87	B88	B89	B90	B91	B92	B93
D	F	P	L	R	L	E	L
B94	B95	B96	B97	B98	B99	B100	B101
A	A	P	S	Q	T	S	V
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	T	Y	H
B114	B115	B116	B117	B118	B119	B120	B121
G	T	G	Y	F	G	E	G
B122	B123	B124	B125	B126	B127
S	W	L	T	V	V

FASTA file

A2	A3	A4	A5	A6	A7	A8	A9
I	Q	V	E	Q	S	P	P
A10	A11	A12	A13	A14	A15	A16	A17
D	L	I	L	Q	E	G	A
A18	A19	A20	A21	A22	A23	A24	A25
N	S	T	L	R	C	N	F
A26	A27	A28	A29	A37	A38	A39	A40
S	D	S	V	N	N	L	Q
A41	A42	A43	A44	A45	A46	A47	A48
W	F	H	Q	N	P	W	G
A49	A50	A51	A52	A53	A54	A55	A56
Q	L	I	N	L	F	Y	I
A57	A58	A64	A65	A66	A67	A68	A74
P	S	G	T	K	Q	N	G
A75	A76	A77	A78	A79	A80	A81	A82
R	L	S	A	T	T	V	A
A83	A84	A85	A86	A87	A88	A89	A90
T	E	R	Y	S	L	L	Y
A91	A92	A93	A94	A95	A96	A97	A98
I	S	S	S	Q	T	T	D
A99	A100	A101	A102	A103	A104	A105	A106
S	G	V	Y	F	C	A	A
A107	A108	A109	A110	A113	A114	A115	A116
L	I	Q	G	A	Q	K	L
A117	A118	A119	A120	A121	A122	A123	A124
V	F	G	Q	G	T	R	L
A125	A126	A127	A128
T	I	N	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASTYHGTGY	None	9
CDRB2	SVGAGI	None	6
CDRB1	MNHNY	None	5
CDRA3	AALIQGAQKLV	A3-11-B	11
CDRA2	IPSGT	None	5
CDRA1	DSVNN	A1-5-B	5

Orientation and docking angles:

Angle	Value
BC2	100.65°
BC1	66.15°
BA	-47.96°
AC2	83.19°
AC1	127.36°
dc	16.72Å
Docking angle	42.98°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
2iam_DC	100.10°	66.38°	-46.77°	85.29°	127.34°	16.86Å	2.5
8eo8_ON	99.21°	66.73°	-47.23°	81.93°	129.12°	17.51Å	2.9
8eo8_JI	99.78°	66.91°	-47.34°	81.05°	128.79°	17.46Å	3.0
8eo8_TS	98.73°	66.45°	-47.32°	82.04°	129.10°	17.47Å	3.0
8eo8_ED	99.44°	67.05°	-46.51°	81.67°	128.90°	17.38Å	3.1

J / I

TCR Details:

Item	Info
VB chain	J
VA chain	I
VB IMGT details	TRBV6/TRBJ1
VA IMGT details	TRAV22/TRAJ54
Species	human

Antigen Details:

Item	Info
Antigen Chain	H
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	GELIGTLNAAKVPAD
Antigen Length	15

MHC details:

Item	Info
MHC Chain	F \| G
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DRA0101 / HLA-DRB10101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
N	A	G	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
K	F	R	I	L	K	I	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	M	T	L	Q	C	T
B25	B26	B27	B28	B29	B37	B38	B39
Q	D	M	N	H	N	Y	M
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	D	P	G
B48	B49	B50	B51	B52	B53	B54	B55
M	G	L	K	L	I	Y	Y
B56	B57	B58	B63	B64	B65	B66	B67
S	V	G	A	G	I	T	D
B68	B69	B70	B71	B72	B74	B75	B76
K	G	E	V	P	N	G	Y
B77	B78	B79	B80	B81	B83	B84	B85
N	V	S	R	S	T	T	E
B86	B87	B88	B89	B90	B91	B92	B93
D	F	P	L	R	L	E	L
B94	B95	B96	B97	B98	B99	B100	B101
A	A	P	S	Q	T	S	V
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	T	Y	H
B114	B115	B116	B117	B118	B119	B120	B121
G	T	G	Y	F	G	E	G
B122	B123	B124	B125	B126	B127
S	W	L	T	V	V

FASTA file

A2	A3	A4	A5	A6	A7	A8	A9
I	Q	V	E	Q	S	P	P
A10	A11	A12	A13	A14	A15	A16	A17
D	L	I	L	Q	E	G	A
A18	A19	A20	A21	A22	A23	A24	A25
N	S	T	L	R	C	N	F
A26	A27	A28	A29	A37	A38	A39	A40
S	D	S	V	N	N	L	Q
A41	A42	A43	A44	A45	A46	A47	A48
W	F	H	Q	N	P	W	G
A49	A50	A51	A52	A53	A54	A55	A56
Q	L	I	N	L	F	Y	I
A57	A58	A64	A65	A66	A67	A68	A74
P	S	G	T	K	Q	N	G
A75	A76	A77	A78	A79	A80	A81	A82
R	L	S	A	T	T	V	A
A83	A84	A85	A86	A87	A88	A89	A90
T	E	R	Y	S	L	L	Y
A91	A92	A93	A94	A95	A96	A97	A98
I	S	S	S	Q	T	T	D
A99	A100	A101	A102	A103	A104	A105	A106
S	G	V	Y	F	C	A	A
A107	A108	A109	A110	A113	A114	A115	A116
L	I	Q	G	A	Q	K	L
A117	A118	A119	A120	A121	A122	A123	A124
V	F	G	Q	G	T	R	L
A125	A126	A127	A128
T	I	N	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASTYHGTGY	None	9
CDRB2	SVGAGI	None	6
CDRB1	MNHNY	None	5
CDRA3	AALIQGAQKLV	A3-11-B	11
CDRA2	IPSGT	None	5
CDRA1	DSVNN	A1-5-B	5

Orientation and docking angles:

Angle	Value
BC2	100.91°
BC1	66.48°
BA	-48.43°
AC2	82.81°
AC1	127.05°
dc	16.72Å
Docking angle	42.81°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
5hho_ED	101.56°	67.45°	-50.20°	81.53°	128.75°	17.08Å	3.0
8eo8_JI	99.78°	66.91°	-47.34°	81.05°	128.79°	17.46Å	3.1
2iam_DC	100.10°	66.38°	-46.77°	85.29°	127.34°	16.86Å	3.1
8eo8_ON	99.21°	66.73°	-47.23°	81.93°	129.12°	17.51Å	3.2
8en8_ED	99.32°	66.55°	-48.01°	80.60°	128.61°	17.34Å	3.2

O / N

TCR Details:

Item	Info
VB chain	O
VA chain	N
VB IMGT details	TRBV6/TRBJ1
VA IMGT details	TRAV22/TRAJ54
Species	human

Antigen Details:

Item	Info
Antigen Chain	M
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	GELIGTLNAAKVPAD
Antigen Length	15

MHC details:

Item	Info
MHC Chain	K \| L
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DRA0101 / HLA-DRB10101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
N	A	G	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
K	F	R	I	L	K	I	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	M	T	L	Q	C	T
B25	B26	B27	B28	B29	B37	B38	B39
Q	D	M	N	H	N	Y	M
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	D	P	G
B48	B49	B50	B51	B52	B53	B54	B55
M	G	L	K	L	I	Y	Y
B56	B57	B58	B63	B64	B65	B66	B67
S	V	G	A	G	I	T	D
B68	B69	B70	B71	B72	B74	B75	B76
K	G	E	V	P	N	G	Y
B77	B78	B79	B80	B81	B83	B84	B85
N	V	S	R	S	T	T	E
B86	B87	B88	B89	B90	B91	B92	B93
D	F	P	L	R	L	E	L
B94	B95	B96	B97	B98	B99	B100	B101
A	A	P	S	Q	T	S	V
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	T	Y	H
B114	B115	B116	B117	B118	B119	B120	B121
G	T	G	Y	F	G	E	G
B122	B123	B124	B125	B126	B127
S	W	L	T	V	V

FASTA file

A2	A3	A4	A5	A6	A7	A8	A9
I	Q	V	E	Q	S	P	P
A10	A11	A12	A13	A14	A15	A16	A17
D	L	I	L	Q	E	G	A
A18	A19	A20	A21	A22	A23	A24	A25
N	S	T	L	R	C	N	F
A26	A27	A28	A29	A37	A38	A39	A40
S	D	S	V	N	N	L	Q
A41	A42	A43	A44	A45	A46	A47	A48
W	F	H	Q	N	P	W	G
A49	A50	A51	A52	A53	A54	A55	A56
Q	L	I	N	L	F	Y	I
A57	A58	A64	A65	A66	A67	A68	A74
P	S	G	T	K	Q	N	G
A75	A76	A77	A78	A79	A80	A81	A82
R	L	S	A	T	T	V	A
A83	A84	A85	A86	A87	A88	A89	A90
T	E	R	Y	S	L	L	Y
A91	A92	A93	A94	A95	A96	A97	A98
I	S	S	S	Q	T	T	D
A99	A100	A101	A102	A103	A104	A105	A106
S	G	V	Y	F	C	A	A
A107	A108	A109	A110	A113	A114	A115	A116
L	I	Q	G	A	Q	K	L
A117	A118	A119	A120	A121	A122	A123	A124
V	F	G	Q	G	T	R	L
A125	A126	A127	A128
T	I	N	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASTYHGTGY	None	9
CDRB2	SVGAGI	None	6
CDRB1	MNHNY	None	5
CDRA3	AALIQGAQKLV	A3-11-B	11
CDRA2	IPSGT	None	5
CDRA1	DSVNN	A1-5-B	5

Orientation and docking angles:

Angle	Value
BC2	100.39°
BC1	65.95°
BA	-46.45°
AC2	85.10°
AC1	127.80°
dc	16.91Å
Docking angle	42.04°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
2iam_DC	100.10°	66.38°	-46.77°	85.29°	127.34°	16.86Å	0.8
8en8_JI	99.10°	66.80°	-45.73°	83.58°	129.37°	17.46Å	2.8
8enh_ON	99.38°	66.72°	-46.36°	82.45°	129.26°	17.57Å	3.3
8es9_BA	99.43°	67.31°	-47.86°	87.02°	128.97°	18.02Å	3.3
8enh_TS	98.70°	66.39°	-46.25°	82.78°	129.52°	17.52Å	3.4

T / S

TCR Details:

Item	Info
VB chain	T
VA chain	S
VB IMGT details	TRBV6/TRBJ1
VA IMGT details	TRAV22/TRAJ54
Species	human

Antigen Details:

Item	Info
Antigen Chain	R
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	GELIGTLNAAKVPAD
Antigen Length	15

MHC details:

Item	Info
MHC Chain	P \| Q
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DRA0101 / HLA-DRB10101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
N	A	G	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
K	F	R	I	L	K	I	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	S	M	T	L	Q	C	T
B25	B26	B27	B28	B29	B37	B38	B39
Q	D	M	N	H	N	Y	M
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	D	P	G
B48	B49	B50	B51	B52	B53	B54	B55
M	G	L	K	L	I	Y	Y
B56	B57	B58	B63	B64	B65	B66	B67
S	V	G	A	G	I	T	D
B68	B69	B70	B71	B72	B74	B75	B76
K	G	E	V	P	N	G	Y
B77	B78	B79	B80	B81	B83	B84	B85
N	V	S	R	S	T	T	E
B86	B87	B88	B89	B90	B91	B92	B93
D	F	P	L	R	L	E	L
B94	B95	B96	B97	B98	B99	B100	B101
A	A	P	S	Q	T	S	V
B102	B103	B104	B105	B106	B107	B108	B109
Y	F	C	A	S	T	Y	H
B114	B115	B116	B117	B118	B119	B120	B121
G	T	G	Y	F	G	E	G
B122	B123	B124	B125	B126	B127
S	W	L	T	V	V

FASTA file

A2	A3	A4	A5	A6	A7	A8	A9
I	Q	V	E	Q	S	P	P
A10	A11	A12	A13	A14	A15	A16	A17
D	L	I	L	Q	E	G	A
A18	A19	A20	A21	A22	A23	A24	A25
N	S	T	L	R	C	N	F
A26	A27	A28	A29	A37	A38	A39	A40
S	D	S	V	N	N	L	Q
A41	A42	A43	A44	A45	A46	A47	A48
W	F	H	Q	N	P	W	G
A49	A50	A51	A52	A53	A54	A55	A56
Q	L	I	N	L	F	Y	I
A57	A58	A64	A65	A66	A67	A68	A74
P	S	G	T	K	Q	N	G
A75	A76	A77	A78	A79	A80	A81	A82
R	L	S	A	T	T	V	A
A83	A84	A85	A86	A87	A88	A89	A90
T	E	R	Y	S	L	L	Y
A91	A92	A93	A94	A95	A96	A97	A98
I	S	S	S	Q	T	T	D
A99	A100	A101	A102	A103	A104	A105	A106
S	G	V	Y	F	C	A	A
A107	A108	A109	A110	A113	A114	A115	A116
L	I	Q	G	A	Q	K	L
A117	A118	A119	A120	A121	A122	A123	A124
V	F	G	Q	G	T	R	L
A125	A126	A127	A128
T	I	N	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASTYHGTGY	None	9
CDRB2	SVGAGI	None	6
CDRB1	MNHNY	None	5
CDRA3	AALIQGAQKLV	A3-11-B	11
CDRA2	IPSGT	None	5
CDRA1	DSVNN	A1-5-B	5

Orientation and docking angles:

Angle	Value
BC2	100.53°
BC1	65.98°
BA	-47.12°
AC2	84.53°
AC1	127.43°
dc	16.86Å
Docking angle	43.31°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
2iam_DC	100.10°	66.38°	-46.77°	85.29°	127.34°	16.86Å	1.0
8en8_JI	99.10°	66.80°	-45.73°	83.58°	129.37°	17.46Å	3.1
8enh_ON	99.38°	66.72°	-46.36°	82.45°	129.26°	17.57Å	3.3
8eo8_ON	99.21°	66.73°	-47.23°	81.93°	129.12°	17.51Å	3.5
8enh_TS	98.70°	66.39°	-46.25°	82.78°	129.52°	17.52Å	3.5

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link