Details for 5hhm

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Structure information

Crystal Structure of the Jm22 TCR in complex with HLA-A*0201 in complex with M1-F5L

Item	Info
PDB	5hhm
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.5Å
Number of TCRs	2

Paired chains information

This PDB has 2 TCR(s).

E / D

TCR Details:

Item	Info
VB chain	E
VA chain	D
VB IMGT details	TRBV19/TRBJ2
VA IMGT details	TRAV27/TRAJ42
Species	human

Antigen Details:

Item	Info
Antigen Chain	C
Antigen Type	Peptide
Antigen Organism	SYNTHETIC CONSTRUCT
Antigen Sequence	GILGLVFTL
Antigen Length	9

MHC details:

Item	Info
MHC Chain	A \| B
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*0201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
G	G	I	T	Q	S	P	K
B10	B11	B12	B13	B14	B15	B16	B17
Y	L	F	R	K	E	G	Q
B18	B19	B20	B21	B22	B23	B24	B25
N	V	T	L	S	C	E	Q
B26	B27	B28	B29	B37	B38	B39	B40
N	L	N	H	D	A	M	Y
B41	B42	B43	B44	B45	B46	B47	B48
W	Y	R	Q	D	P	G	Q
B49	B50	B51	B52	B53	B54	B55	B56
G	L	R	L	I	Y	Y	S
B57	B58	B63	B64	B65	B66	B67	B68
Q	I	V	N	D	F	Q	K
B69	B70	B71	B72	B74	B75	B76	B77
G	D	I	A	E	G	Y	S
B78	B79	B80	B81	B83	B84	B85	B86
V	S	R	E	K	K	E	S
B87	B88	B89	B90	B91	B92	B93	B94
F	P	L	T	V	T	S	A
B95	B96	B97	B98	B99	B100	B101	B102
Q	K	N	P	T	A	F	Y
B103	B104	B105	B106	B107	B108	B109	B110
L	C	A	S	S	S	R	S
B113	B114	B115	B116	B117	B118	B119	B120
S	Y	E	Q	Y	F	G	P
B121	B122	B123	B124	B125	B126	B127
G	T	R	L	T	V	T

FASTA file

A3	A4	A5	A6	A7	A8	A9	A10
L	L	E	Q	S	P	Q	F
A11	A12	A13	A14	A15	A16	A17	A18
L	S	I	Q	E	G	E	N
A19	A20	A21	A22	A23	A24	A25	A26
L	T	V	Y	C	N	S	S
A27	A28	A29	A37	A38	A39	A40	A41
S	V	F	S	S	L	Q	W
A42	A43	A44	A45	A46	A47	A48	A49
Y	R	Q	E	P	G	E	G
A50	A51	A52	A53	A54	A55	A56	A57
P	V	L	L	V	T	V	V
A58	A59	A63	A64	A65	A66	A67	A68
T	G	G	E	V	K	K	L
A74	A75	A76	A77	A78	A79	A80	A81
K	R	L	T	F	Q	F	G
A82	A83	A84	A85	A86	A87	A88	A89
D	A	R	K	D	S	S	L
A90	A91	A92	A93	A94	A95	A96	A97
H	I	T	A	A	Q	P	G
A98	A99	A100	A101	A102	A103	A104	A105
D	T	G	L	Y	L	C	A
A106	A107	A108	A109	A113	A114	A115	A116
G	A	G	S	Q	G	N	L
A117	A118	A119	A120	A121	A122	A123	A124
I	F	G	K	G	T	K	L
A125	A126	A127	A128
S	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSSRSSYEQY	None	11
CDRB2	SQIVND	None	6
CDRB1	LNHDA	None	5
CDRA3	AGAGSQGNLI	A3-10-C	10
CDRA2	VVTGGEV	None	7
CDRA1	SVFSS	None	5

Orientation and docking angles:

Angle	Value
BC2	101.72°
BC1	67.97°
BA	-50.56°
AC2	81.00°
AC1	128.78°
dc	16.94Å
Docking angle	63.90°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
2vlr_ED	101.89°	68.24°	-50.85°	80.78°	128.30°	17.33Å	0.8
5hho_ED	101.56°	67.45°	-50.20°	81.53°	128.75°	17.08Å	0.9
2vlr_JI	102.60°	68.26°	-50.48°	80.59°	128.66°	17.58Å	1.2
1oga_ED	101.63°	66.96°	-50.54°	80.21°	129.12°	17.20Å	1.4
2vlk_ED	102.53°	68.22°	-50.04°	80.54°	127.47°	17.33Å	1.8

J / I

TCR Details:

Item	Info
VB chain	J
VA chain	I
VB IMGT details	TRBV19/TRBJ2
VA IMGT details	TRAV27/TRAJ42
Species	human

Antigen Details:

Item	Info
Antigen Chain	H
Antigen Type	Peptide
Antigen Organism	SYNTHETIC CONSTRUCT
Antigen Sequence	GILGLVFTL
Antigen Length	9

MHC details:

Item	Info
MHC Chain	F \| G
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*0201

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B2	B3	B4	B5	B6	B7	B8	B9
G	G	I	T	Q	S	P	K
B10	B11	B12	B13	B14	B15	B16	B17
Y	L	F	R	K	E	G	Q
B18	B19	B20	B21	B22	B23	B24	B25
N	V	T	L	S	C	E	Q
B26	B27	B28	B29	B37	B38	B39	B40
N	L	N	H	D	A	M	Y
B41	B42	B43	B44	B45	B46	B47	B48
W	Y	R	Q	D	P	G	Q
B49	B50	B51	B52	B53	B54	B55	B56
G	L	R	L	I	Y	Y	S
B57	B58	B63	B64	B65	B66	B67	B68
Q	I	V	N	D	F	Q	K
B69	B70	B71	B72	B74	B75	B76	B77
G	D	I	A	E	G	Y	S
B78	B79	B80	B81	B83	B84	B85	B86
V	S	R	E	K	K	E	S
B87	B88	B89	B90	B91	B92	B93	B94
F	P	L	T	V	T	S	A
B95	B96	B97	B98	B99	B100	B101	B102
Q	K	N	P	T	A	F	Y
B103	B104	B105	B106	B107	B108	B109	B110
L	C	A	S	S	S	R	S
B113	B114	B115	B116	B117	B118	B119	B120
S	Y	E	Q	Y	F	G	P
B121	B122	B123	B124	B125	B126	B127
G	T	R	L	T	V	T

FASTA file

A3	A4	A5	A6	A7	A8	A9	A10
L	L	E	Q	S	P	Q	F
A11	A12	A13	A14	A15	A16	A17	A18
L	S	I	Q	E	G	E	N
A19	A20	A21	A22	A23	A24	A25	A26
L	T	V	Y	C	N	S	S
A27	A28	A29	A37	A38	A39	A40	A41
S	V	F	S	S	L	Q	W
A42	A43	A44	A45	A46	A47	A48	A49
Y	R	Q	E	P	G	E	G
A50	A51	A52	A53	A54	A55	A56	A57
P	V	L	L	V	T	V	V
A58	A59	A63	A64	A65	A66	A67	A68
T	G	G	E	V	K	K	L
A74	A75	A76	A77	A78	A79	A80	A81
K	R	L	T	F	Q	F	G
A82	A83	A84	A85	A86	A87	A88	A89
D	A	R	K	D	S	S	L
A90	A91	A92	A93	A94	A95	A96	A97
H	I	T	A	A	Q	P	G
A98	A99	A100	A101	A102	A103	A104	A105
D	T	G	L	Y	L	C	A
A106	A107	A108	A109	A113	A114	A115	A116
G	A	G	S	Q	G	N	L
A117	A118	A119	A120	A121	A122	A123	A124
I	F	G	K	G	T	K	L
A125	A126	A127	A128
S	V	K	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSSRSSYEQY	None	11
CDRB2	SQIVND	None	6
CDRB1	LNHDA	None	5
CDRA3	AGAGSQGNLI	A3-10-C	10
CDRA2	VVTGGEV	None	7
CDRA1	SVFSS	None	5

Orientation and docking angles:

Angle	Value
BC2	102.11°
BC1	67.67°
BA	-50.24°
AC2	81.42°
AC1	128.65°
dc	17.00Å
Docking angle	63.90°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
5hho_ED	101.56°	67.45°	-50.20°	81.53°	128.75°	17.08Å	0.6
2vlr_ED	101.89°	68.24°	-50.85°	80.78°	128.30°	17.33Å	1.2
2vlr_JI	102.60°	68.26°	-50.48°	80.59°	128.66°	17.58Å	1.3
1oga_ED	101.63°	66.96°	-50.54°	80.21°	129.12°	17.20Å	1.6
2vlk_ED	102.53°	68.22°	-50.04°	80.54°	127.47°	17.33Å	1.7

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link