Details for 7ea6

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Structure information

Crystal Structure of TCR-017 Ectodomain

Item	Info
PDB	7ea6
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.18Å
Number of TCRs	2

Paired chains information

This PDB has 2 TCR(s).

B / A

TCR Details:

Item	Info
VB chain	B
VA chain	A
VB IMGT details	TRBV11/TRBJ2
VA IMGT details	TRAV12/TRAJ12
Species	human

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B3	B4	B5	B6	B7	B8	B9	B10
G	V	A	Q	S	P	R	Y
B11	B12	B13	B14	B15	B16	B17	B18
K	I	I	E	K	R	Q	S
B19	B20	B21	B22	B23	B24	B25	B26
V	A	F	W	C	N	P	I
B27	B28	B29	B37	B38	B39	B40	B41
S	G	H	A	T	L	Y	W
B42	B43	B44	B45	B46	B47	B48	B49
Y	Q	Q	I	L	G	Q	G
B50	B51	B52	B53	B54	B55	B56	B57
P	K	L	L	I	Q	F	Q
B58	B63	B64	B65	B66	B67	B68	B69
N	N	G	V	V	D	D	S
B70	B71	B72	B73	B74	B75	B76	B77
Q	L	P	K	D	R	F	S
B78	B79	B80	B81	B83	B84	B85	B86
A	E	R	L	K	G	V	D
B87	B88	B89	B90	B91	B92	B93	B94
S	T	L	K	I	Q	P	A
B95	B96	B97	B98	B99	B100	B101	B102
K	L	E	D	S	A	V	Y
B103	B104	B105	B106	B107	B108	B109	B114
L	C	A	S	S	Q	T	Y
B115	B116	B117	B118	B119	B120	B121	B122
E	Q	Y	F	G	P	G	T
B123	B124	B125	B126	B127
R	L	T	V	T

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
R	K	E	V	E	Q	D	P
A9	A10	A11	A12	A13	A14	A15	A16
G	P	F	N	V	P	E	G
A17	A18	A19	A20	A21	A22	A23	A24
A	T	V	A	F	N	C	T
A25	A26	A27	A28	A29	A36	A37	A38
Y	S	N	S	A	S	Q	S
A39	A40	A41	A42	A43	A44	A45	A46
F	F	W	Y	R	Q	D	C
A47	A48	A49	A50	A51	A52	A53	A54
R	K	E	P	K	L	L	M
A55	A56	A57	A58	A64	A65	A66	A67
S	V	Y	S	S	G	N	E
A68	A74	A75	A76	A77	A78	A79	A80
D	G	R	F	T	A	Q	L
A81	A82	A83	A84	A85	A86	A87	A88
N	R	A	S	Q	Y	I	S
A89	A90	A91	A92	A93	A94	A95	A96
L	L	I	R	D	S	K	L
A97	A98	A99	A100	A101	A102	A103	A104
S	D	S	A	T	Y	L	C
A105	A106	A107	A108	A109	A110	A113	A114
V	V	N	R	G	S	S	Y
A115	A116	A117	A118	A119	A120	A121	A122
K	L	I	F	G	S	G	T
A123	A124	A125	A126	A127	A128
R	L	L	V	R	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSQTYEQY	None	9
CDRB2	FQNNGV	None	6
CDRB1	SGHAT	None	5
CDRA3	VVNRGSSYKLI	None	11
CDRA2	VYSSG	None	5
CDRA1	NSASQS	None	6

Orientation and docking angles:

Angle	Value
BC2	102.15°
BC1	75.20°
BA	-54.88°
AC2	77.43°
AC1	125.68°
dc	16.05Å

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
1nfd_DC	101.71°	72.76°	-53.95°	78.25°	126.45°	16.86Å	3.0
4qrp_ED	101.66°	74.29°	-56.57°	79.64°	125.83°	16.91Å	3.1
7pb2_ED	103.19°	73.44°	-57.08°	77.02°	125.99°	16.87Å	3.2
6tro_ED	101.60°	73.22°	-56.62°	75.68°	125.70°	17.35Å	3.5
7pb2_JI	103.13°	73.39°	-57.79°	76.91°	125.64°	16.86Å	3.7

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4yfl_HL	109.78°	73.75°	-56.79°	79.59°	122.71°	16.13Å	8.8
3mnw_BA	107.15°	71.13°	-53.34°	82.80°	121.51°	16.47Å	9.5
3bgf_BC	109.96°	71.90°	-55.10°	81.62°	123.51°	15.76Å	9.7
3mnz_BA	108.41°	71.26°	-53.27°	82.05°	121.70°	16.38Å	9.7
1fj1_DC	109.78°	71.11°	-51.69°	80.11°	123.02°	16.12Å	10.0

E / D

TCR Details:

Item	Info
VB chain	E
VA chain	D
VB IMGT details	TRBV11/TRBJ2
VA IMGT details	TRAV12/TRAJ12
Species	human

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B3	B4	B5	B6	B7	B8	B9	B10
G	V	A	Q	S	P	R	Y
B11	B12	B13	B14	B15	B16	B17	B18
K	I	I	E	K	R	Q	S
B19	B20	B21	B22	B23	B24	B25	B26
V	A	F	W	C	N	P	I
B27	B28	B29	B37	B38	B39	B40	B41
S	G	H	A	T	L	Y	W
B42	B43	B44	B45	B46	B47	B48	B49
Y	Q	Q	I	L	G	Q	G
B50	B51	B52	B53	B54	B55	B56	B57
P	K	L	L	I	Q	F	Q
B58	B63	B64	B65	B66	B67	B68	B69
N	N	G	V	V	D	D	S
B70	B71	B72	B73	B74	B75	B76	B77
Q	L	P	K	D	R	F	S
B78	B79	B80	B81	B83	B84	B85	B86
A	E	R	L	K	G	V	D
B87	B88	B89	B90	B91	B92	B93	B94
S	T	L	K	I	Q	P	A
B95	B96	B97	B98	B99	B100	B101	B102
K	L	E	D	S	A	V	Y
B103	B104	B105	B106	B107	B108	B109	B114
L	C	A	S	S	Q	T	Y
B115	B116	B117	B118	B119	B120	B121	B122
E	Q	Y	F	G	P	G	T
B123	B124	B125	B126	B127
R	L	T	V	T

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
R	K	E	V	E	Q	D	P
A9	A10	A11	A12	A13	A14	A15	A16
G	P	F	N	V	P	E	G
A17	A18	A19	A20	A21	A22	A23	A24
A	T	V	A	F	N	C	T
A25	A26	A27	A28	A29	A36	A37	A38
Y	S	N	S	A	S	Q	S
A39	A40	A41	A42	A43	A44	A45	A46
F	F	W	Y	R	Q	D	C
A47	A48	A49	A50	A51	A52	A53	A54
R	K	E	P	K	L	L	M
A55	A56	A57	A58	A64	A65	A66	A67
S	V	Y	S	S	G	N	E
A68	A74	A75	A76	A77	A78	A79	A80
D	G	R	F	T	A	Q	L
A81	A82	A83	A84	A85	A86	A87	A88
N	R	A	S	Q	Y	I	S
A89	A90	A91	A92	A93	A94	A95	A96
L	L	I	R	D	S	K	L
A97	A98	A99	A100	A101	A102	A103	A104
S	D	S	A	T	Y	L	C
A105	A106	A107	A108	A109	A110	A113	A114
V	V	N	R	G	S	S	Y
A115	A116	A117	A118	A119	A120	A121	A122
K	L	I	F	G	S	G	T
A123	A124	A125	A126	A127	A128
R	L	L	V	R	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSQTYEQY	None	9
CDRB2	FQNNGV	None	6
CDRB1	SGHAT	None	5
CDRA3	VVNRGSSYKLI	None	11
CDRA2	VYSSG	None	5
CDRA1	NSASQS	None	6

Orientation and docking angles:

Angle	Value
BC2	102.04°
BC1	74.95°
BA	-55.85°
AC2	77.35°
AC1	124.96°
dc	16.22Å

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
7pb2_ED	103.19°	73.44°	-57.08°	77.02°	125.99°	16.87Å	2.6
4qrp_ED	101.66°	74.29°	-56.57°	79.64°	125.83°	16.91Å	2.8
7pb2_JI	103.13°	73.39°	-57.79°	76.91°	125.64°	16.86Å	2.9
6tro_ED	101.60°	73.22°	-56.62°	75.68°	125.70°	17.35Å	2.9
4qrp_IJ	100.97°	74.27°	-58.85°	78.00°	124.47°	16.72Å	3.4

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4yfl_HL	109.78°	73.75°	-56.79°	79.59°	122.71°	16.13Å	8.5
3mnw_BA	107.15°	71.13°	-53.34°	82.80°	121.51°	16.47Å	9.4
3bgf_BC	109.96°	71.90°	-55.10°	81.62°	123.51°	15.76Å	9.7
3mnz_BA	108.41°	71.26°	-53.27°	82.05°	121.70°	16.38Å	9.7

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link