Structure summary for 8en8

Detailed entry information.

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Details for 8en8

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Structure information

Cross-Reactive 3180 TCR Recognition of HLA-B*35:01-Np4 Epitope From 1972 influenza Strain

ItemInfo
PDB8en8
OrganismHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.70001Å
Number of TCRs2
Paired chains information

This PDB has 2 TCR(s).

E / D
TCR Details:
ItemInfo
VB chainE
VA chainD
VB IMGT detailsTRBV20/TRBJ2
VA IMGT detailsTRAV13/TRAJ28
Specieshuman
Antigen Details:
ItemInfo
Antigen ChainC
Antigen TypePeptide
Antigen OrganismINFLUENZA A VIRUS (STRAIN A/MEMPHIS/101/1972H3N2)
Antigen SequenceLPFDKSTIM
Antigen Length9
MHC details:
ItemInfo
MHC ChainA | B
MHC TypeMH1
MHC Specieshuman
MHC IMGT detailsHLA-B*3501
Numbered sequence
Chain typeChain IDFASTA/Annotation fileIMGT numbered sequence (Framework/CDR)
VBE FASTA file
B3 B4 B5 B6 B7 B8 B9 B10
V V S Q H P S R
B11 B12 B13 B14 B15 B16 B17 B18
V I C K S G T S
B19 B20 B21 B22 B23 B24 B25 B26
V K I E C R S L
B27 B28 B29 B36 B37 B38 B39 B40
D F Q A T T M F
B41 B42 B43 B44 B45 B46 B47 B48
W Y R Q F P K Q
B49 B50 B51 B52 B53 B54 B55 B56
S L M L M A T S
B57 B58 B59 B63 B64 B65 B66 B67
N E G S K A T Y
B68 B69 B70 B71 B72 B73 B74 B75
E Q G V E K D K
B76 B77 B78 B79 B80 B81 B83 B84
F L I N H A S L
B85 B86 B87 B88 B89 B90 B91 B92
T L S T L T V T
B93 B94 B95 B96 B97 B98 B99 B100
S A H P E D S S
B101 B102 B103 B104 B105 B106 B107 B108
F Y I C S A G P
B109 B110 B111 B112 B113 B114 B115 B116
T S G R T D T Q
B117 B118 B119 B120 B121 B122 B123 B124
Y F G P G T R L
B125 B126 B127
T V L
VAD FASTA file
A1 A2 A3 A4 A5 A6 A7 A8
G E N V E Q H P
A9 A10 A11 A12 A13 A14 A15 A16
S T L S V Q E G
A17 A18 A19 A20 A21 A22 A23 A24
D S A V I K C T
A25 A26 A27 A28 A29 A36 A37 A38
Y S D S A S N Y
A39 A40 A41 A42 A43 A44 A45 A46
F P W Y K Q E L
A47 A48 A49 A50 A51 A52 A53 A54
G K R P Q L I I
A55 A56 A57 A58 A59 A63 A64 A65
D I R S N V G E
A66 A67 A68 A74 A75 A76 A77 A78
K K D Q R I A V
A79 A80 A81 A82 A83 A84 A85 A86
T L N K T A K H
A87 A88 A89 A90 A91 A92 A93 A94
F S L H I T E T
A95 A96 A97 A98 A99 A100 A101 A102
Q P E D S A V Y
A103 A104 A105 A106 A107 A108 A109 A110
F C A A D G G A
A112 A113 A114 A115 A116 A117 A118 A119
G S Y Q L T F G
A120 A121 A122 A123 A124 A125 A126 A127
K G T K L S V I
A128
P
CDR Sequences:
LoopSequencePredicted canonical formCDR Length
CDRB3SAGPTSGRTDTQYNone13
CDRB2SNEGSKANone7
CDRB1DFQATTNone6
CDRA3AADGGAGSYQLTNone12
CDRA2IRSNVGENone7
CDRA1DSASNYNone6
Orientation and docking angles:
AngleValue
BC299.32°
BC166.55°
BA-48.01°
AC280.60°
AC1128.61°
dc17.34Å
Docking angle41.97°
TCRs with similar orientations:
TCR PDBBC2BC1BAAC2AC1dcTRangle Distance
8eo8_JI 99.78° 66.91° -47.34° 81.05° 128.79° 17.46Å 1.0
8eo8_ON 99.21° 66.73° -47.23° 81.93° 129.12° 17.51Å 1.6
8eo8_TS 98.73° 66.45° -47.32° 82.04° 129.10° 17.47Å 1.8
8eo8_ED 99.44° 67.05° -46.51° 81.67° 128.90° 17.38Å 1.9
8enh_JI 100.05° 66.85° -46.52° 81.14° 129.31° 17.53Å 1.9

J / I
TCR Details:
ItemInfo
VB chainJ
VA chainI
VB IMGT detailsTRBV20/TRBJ2
VA IMGT detailsTRAV13/TRAJ28
Specieshuman
Antigen Details:
ItemInfo
Antigen ChainH
Antigen TypePeptide
Antigen OrganismINFLUENZA A VIRUS (STRAIN A/MEMPHIS/101/1972H3N2)
Antigen SequenceLPFDKSTIM
Antigen Length9
MHC details:
ItemInfo
MHC ChainF | G
MHC TypeMH1
MHC Specieshuman
MHC IMGT detailsHLA-B*3501
Numbered sequence
Chain typeChain IDFASTA/Annotation fileIMGT numbered sequence (Framework/CDR)
VBJ FASTA file
B3 B4 B5 B6 B7 B8 B9 B10
V V S Q H P S R
B11 B12 B13 B14 B15 B16 B17 B18
V I C K S G T S
B19 B20 B21 B22 B23 B24 B25 B26
V K I E C R S L
B27 B28 B29 B36 B37 B38 B39 B40
D F Q A T T M F
B41 B42 B43 B44 B45 B46 B47 B48
W Y R Q F P K Q
B49 B50 B51 B52 B53 B54 B55 B56
S L M L M A T S
B57 B58 B59 B63 B64 B65 B66 B67
N E G S K A T Y
B68 B69 B70 B71 B72 B73 B74 B75
E Q G V E K D K
B76 B77 B78 B79 B80 B81 B83 B84
F L I N H A S L
B85 B86 B87 B88 B89 B90 B91 B92
T L S T L T V T
B93 B94 B95 B96 B97 B98 B99 B100
S A H P E D S S
B101 B102 B103 B104 B105 B106 B107 B108
F Y I C S A G P
B109 B110 B111 B112 B113 B114 B115 B116
T S G R T D T Q
B117 B118 B119 B120 B121 B122 B123 B124
Y F G P G T R L
B125 B126 B127
T V L
VAI FASTA file
A1 A2 A3 A4 A5 A6 A7 A8
G E N V E Q H P
A9 A10 A11 A12 A13 A14 A15 A16
S T L S V Q E G
A17 A18 A19 A20 A21 A22 A23 A24
D S A V I K C T
A25 A26 A27 A28 A29 A36 A37 A38
Y S D S A S N Y
A39 A40 A41 A42 A43 A44 A45 A46
F P W Y K Q E L
A47 A48 A49 A50 A51 A52 A53 A54
G K R P Q L I I
A55 A56 A57 A58 A59 A63 A64 A65
D I R S N V G E
A66 A67 A68 A74 A75 A76 A77 A78
K K D Q R I A V
A79 A80 A81 A82 A83 A84 A85 A86
T L N K T A K H
A87 A88 A89 A90 A91 A92 A93 A94
F S L H I T E T
A95 A96 A97 A98 A99 A100 A101 A102
Q P E D S A V Y
A103 A104 A105 A106 A107 A108 A109 A110
F C A A D G G A
A112 A113 A114 A115 A116 A117 A118 A119
G S Y Q L T F G
A120 A121 A122 A123 A124 A125 A126 A127
K G T K L S V I
A128
P
CDR Sequences:
LoopSequencePredicted canonical formCDR Length
CDRB3SAGPTSGRTDTQYNone13
CDRB2SNEGSKANone7
CDRB1DFQATTNone6
CDRA3AADGGAGSYQLTNone12
CDRA2IRSNVGENone7
CDRA1DSASNYNone6
Orientation and docking angles:
AngleValue
BC299.10°
BC166.80°
BA-45.73°
AC283.58°
AC1129.37°
dc17.46Å
Docking angle41.85°
TCRs with similar orientations:
TCR PDBBC2BC1BAAC2AC1dcTRangle Distance
8enh_TS 98.70° 66.39° -46.25° 82.78° 129.52° 17.52Å 1.1
8enh_ON 99.38° 66.72° -46.36° 82.45° 129.26° 17.57Å 1.3
8eo8_ED 99.44° 67.05° -46.51° 81.67° 128.90° 17.38Å 2.2
8eo8_ON 99.21° 66.73° -47.23° 81.93° 129.12° 17.51Å 2.2
8enh_ED 99.71° 67.01° -46.00° 81.48° 129.32° 17.41Å 2.2

Available downloads

Additional links and files for download: see help for more details.

ItemLink
IMGT-numbered structureLink
Non-annotated structure from the PDBLink
Summary file for this TCRLink
Link in the PDBLink