Details for 8trl

Click on any of the tabs below to see the detailed information about the structure.

Structure visualisation

Display options:
Cartoon model
Spacefill model
Wire model
Ball&stick model
Default colouring
Color by B-factor
Color by chain
Color by sec. structure
Color by element
Spin: on off

Structure information

T Cell Recognition of Citrullinated alpha-Enolase Peptide Presented By HLA-Dr4

Item	Info
PDB	8trl
Organism	HOMO SAPIENS
Method	X-RAY DIFFRACTION
Resolution	2.4Å
Number of TCRs	2

Paired chains information

This PDB has 2 TCR(s).

H / G

TCR Details:

Item	Info
VB chain	H
VA chain	G
VB IMGT details	TRBV2/TRBJ2
VA IMGT details	TRAV26/TRAJ49
Species	human

Antigen Details:

Item	Info
Antigen Chain	F
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	EIFDSRGNPTGEV
Antigen Length	13

MHC details:

Item	Info
MHC Chain	D \| E
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DRA0101 / HLA-DRB10401

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	P	E	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
S	H	Q	V	T	Q	M	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	E	V	I	L	R	C	V
B25	B26	B27	B28	B29	B37	B38	B39
P	I	S	N	H	L	Y	F
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	I	L	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	K	V	E	F	L	V	S
B56	B57	B58	B63	B64	B65	B66	B67
F	Y	N	N	E	I	S	E
B68	B69	B70	B71	B72	B73	B74	B75
K	S	E	I	F	D	D	Q
B76	B77	B78	B79	B80	B81	B83	B84
F	S	V	E	R	P	D	G
B85	B86	B87	B88	B89	B90	B91	B92
S	N	F	T	L	K	I	R
B93	B94	B95	B96	B97	B98	B99	B100
S	T	K	L	E	D	S	A
B101	B102	B103	B104	B105	B106	B107	B108
M	Y	F	C	A	S	R	R
B109	B110	B112	B113	B114	B115	B116	B117
D	Y	F	S	Y	E	Q	Y
B118	B119	B120	B121	B122	B123	B124	B125
F	G	P	G	T	R	L	T
B126	B127
V	T

FASTA file

A3	A4	A5	A6	A8	A9	A10	A11
K	T	T	Q	P	P	S	M
A12	A13	A14	A15	A16	A17	A18	A19
D	C	A	E	G	R	A	A
A20	A21	A22	A23	A24	A25	A26	A27
N	L	P	C	N	H	S	T
A28	A29	A30	A36	A37	A38	A39	A40
I	S	G	N	E	Y	V	Y
A41	A42	A43	A44	A45	A46	A47	A48
W	Y	R	Q	I	H	S	Q
A49	A50	A51	A52	A53	A54	A55	A56
G	P	Q	Y	I	I	H	G
A57	A58	A64	A65	A66	A67	A68	A74
L	K	N	N	E	T	N	E
A75	A76	A77	A78	A79	A80	A81	A82
M	A	S	L	I	I	T	E
A83	A84	A85	A86	A87	A88	A89	A90
D	R	K	S	S	T	L	I
A91	A92	A93	A94	A95	A96	A97	A98
L	P	H	A	T	L	R	D
A99	A100	A101	A102	A103	A104	A105	A106
T	A	V	Y	Y	C	I	V
A107	A108	A109	A110	A112	A113	A114	A115
N	P	A	N	T	G	N	Q
A116	A117	A118	A119	A120	A121	A122	A123
F	Y	F	G	T	G	T	S
A124	A125	A126	A127	A128
L	T	V	I	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASRRDYFSYEQY	None	12
CDRB2	FYNNEI	None	6
CDRB1	SNHLY	None	5
CDRA3	IVNPANTGNQFY	None	12
CDRA2	GLKNN	None	5
CDRA1	TISGNEY	None	7

Orientation and docking angles:

Angle	Value
BC2	108.52°
BC1	72.50°
BA	-59.82°
AC2	90.22°
AC1	134.25°
dc	17.81Å
Docking angle	33.33°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
3kpr_ED	108.37°	71.95°	-62.50°	91.08°	133.35°	17.66Å	3.0
4z7u_HG	108.35°	73.51°	-58.43°	88.99°	131.96°	17.40Å	3.1
4z7u_FE	107.76°	73.67°	-57.94°	88.53°	131.88°	17.47Å	3.8
3pqy_ED	107.20°	69.52°	-58.40°	89.24°	131.57°	18.08Å	4.6
3kps_ED	108.71°	71.81°	-63.92°	89.41°	132.56°	17.63Å	4.6

J / I

TCR Details:

Item	Info
VB chain	J
VA chain	I
VB IMGT details	TRBV2/TRBJ2
VA IMGT details	TRAV26/TRAJ49
Species	human

Antigen Details:

Item	Info
Antigen Chain	C
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	EIFDSRGNPTGEV
Antigen Length	13

MHC details:

Item	Info
MHC Chain	A \| B
MHC Type	MH2
MHC Species	human
MHC IMGT details	HLA-DRA0101 / HLA-DRB10401

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B1	B2	B3	B4	B5	B6	B7	B8
E	P	E	V	T	Q	T	P
B9	B10	B11	B12	B13	B14	B15	B16
S	H	Q	V	T	Q	M	G
B17	B18	B19	B20	B21	B22	B23	B24
Q	E	V	I	L	R	C	V
B25	B26	B27	B28	B29	B37	B38	B39
P	I	S	N	H	L	Y	F
B40	B41	B42	B43	B44	B45	B46	B47
Y	W	Y	R	Q	I	L	G
B48	B49	B50	B51	B52	B53	B54	B55
Q	K	V	E	F	L	V	S
B56	B57	B58	B63	B64	B65	B66	B67
F	Y	N	N	E	I	S	E
B68	B69	B70	B71	B72	B73	B74	B75
K	S	E	I	F	D	D	Q
B76	B77	B78	B79	B80	B81	B83	B84
F	S	V	E	R	P	D	G
B85	B86	B87	B88	B89	B90	B91	B92
S	N	F	T	L	K	I	R
B93	B94	B95	B96	B97	B98	B99	B100
S	T	K	L	E	D	S	A
B101	B102	B103	B104	B105	B106	B107	B108
M	Y	F	C	A	S	R	R
B109	B110	B112	B113	B114	B115	B116	B117
D	Y	F	S	Y	E	Q	Y
B118	B119	B120	B121	B122	B123	B124	B125
F	G	P	G	T	R	L	T
B126	B127
V	T

FASTA file

A3	A4	A5	A6	A8	A9	A10	A11
K	T	T	Q	P	P	S	M
A12	A13	A14	A15	A16	A17	A18	A19
D	C	A	E	G	R	A	A
A20	A21	A22	A23	A24	A25	A26	A27
N	L	P	C	N	H	S	T
A28	A29	A30	A36	A37	A38	A39	A40
I	S	G	N	E	Y	V	Y
A41	A42	A43	A44	A45	A46	A47	A48
W	Y	R	Q	I	H	S	Q
A49	A50	A51	A52	A53	A54	A55	A56
G	P	Q	Y	I	I	H	G
A57	A58	A64	A65	A66	A67	A68	A74
L	K	N	N	E	T	N	E
A75	A76	A77	A78	A79	A80	A81	A82
M	A	S	L	I	I	T	E
A83	A84	A85	A86	A87	A88	A89	A90
D	R	K	S	S	T	L	I
A91	A92	A93	A94	A95	A96	A97	A98
L	P	H	A	T	L	R	D
A99	A100	A101	A102	A103	A104	A105	A106
T	A	V	Y	Y	C	I	V
A107	A108	A109	A110	A112	A113	A114	A115
N	P	A	N	T	G	N	Q
A116	A117	A118	A119	A120	A121	A122	A123
F	Y	F	G	T	G	T	S
A124	A125	A126	A127	A128
L	T	V	I	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASRRDYFSYEQY	None	12
CDRB2	FYNNEI	None	6
CDRB1	SNHLY	None	5
CDRA3	IVNPANTGNQFY	None	12
CDRA2	GLKNN	None	5
CDRA1	TISGNEY	None	7

Orientation and docking angles:

Angle	Value
BC2	108.73°
BC1	73.20°
BA	-58.64°
AC2	92.22°
AC1	134.56°
dc	17.67Å
Docking angle	34.82°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
4z7u_HG	108.35°	73.51°	-58.43°	88.99°	131.96°	17.40Å	4.2
3kpr_ED	108.37°	71.95°	-62.50°	91.08°	133.35°	17.66Å	4.4
4z7u_FE	107.76°	73.67°	-57.94°	88.53°	131.88°	17.47Å	4.7
4z7v_FE	111.26°	73.06°	-61.69°	93.39°	131.70°	17.14Å	5.1
4z7v_HG	111.21°	73.03°	-62.36°	92.92°	131.88°	17.12Å	5.3

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link