Details for 8wul

Click on any of the tabs below to see the detailed information about the structure.

Structure visualisation

Display options:
Cartoon model
Spacefill model
Wire model
Ball&stick model
Default colouring
Color by B-factor
Color by chain
Color by sec. structure
Color by element
Spin: on off

Structure information

Crystal Structure of affinity Enhanced TCR in complex with HLA-A*11:01 Bound to Kras-G12V Peptide (Vvgavgvgk)

Item	Info
PDB	8wul
Organism	MUS MUSCULUS
Method	X-RAY DIFFRACTION
Resolution	2.36Å
Number of TCRs	4

Paired chains information

This PDB has 4 TCR(s).

B / A

TCR Details:

Item	Info
VB chain	B
VA chain	A
VB IMGT details	TRBV2/TRBJ2
VA IMGT details	TRAV7/TRAJ22
Species	mouse

Antigen Details:

Item	Info
Antigen Chain	K
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	VVGAVGVGK
Antigen Length	9

MHC details:

Item	Info
MHC Chain	I \| J
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*1101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B3	B4	B5	B6	B7	B8	B9	B10
K	I	I	Q	K	P	K	Y
B11	B12	B13	B14	B15	B16	B17	B18
L	V	A	V	T	G	S	E
B19	B20	B21	B22	B23	B24	B25	B26
K	I	L	I	C	E	Q	Y
B27	B28	B29	B37	B38	B39	B40	B41
L	G	H	N	A	M	Y	W
B42	B43	B44	B45	B46	B47	B48	B49
Y	R	Q	S	A	K	K	P
B50	B51	B52	B53	B54	B55	B56	B57
L	E	F	M	F	S	Y	S
B58	B63	B64	B65	B66	B67	B68	B69
Y	Q	M	L	M	D	N	Q
B70	B71	B72	B74	B75	B76	B77	B78
T	A	S	S	R	F	Q	P
B79	B80	B81	B83	B84	B85	B86	B87
Q	S	S	K	K	N	H	L
B88	B89	B90	B91	B92	B93	B94	B95
D	L	Q	I	T	A	L	K
B96	B97	B98	B99	B100	B101	B102	B103
P	D	D	S	A	T	Y	F
B104	B105	B106	B107	B108	B109	B110	B111
C	A	S	S	Q	D	R	G
B112A	B112	B113	B114	B115	B116	B117	B118
D	S	A	H	T	L	Y	F
B119	B120	B121	B122	B123	B124	B125	B126
G	S	G	T	R	L	T	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
Q	Q	K	V	Q	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
E	S	L	I	V	P	E	G
A17	A18	A19	A20	A21	A22	A23	A24
G	M	A	S	L	N	C	T
A25	A26	A27	A28	A29	A36	A37	A38
S	S	D	R	N	V	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	W	W	Y	R	Q	H	S
A47	A48	A49	A50	A51	A52	A53	A54
G	K	S	P	K	M	L	M
A55	A56	A57	A58	A63	A64	A65	A66
S	I	F	S	N	G	E	K
A67	A68	A74	A75	A76	A77	A78	A79
E	E	G	R	F	T	V	H
A80	A81	A82	A83	A84	A85	A86	A87
L	N	K	A	S	L	H	T
A88	A89	A90	A91	A92	A93	A94	A95
S	L	H	I	R	D	S	Q
A96	A97	A98	A99	A100	A101	A102	A103
P	S	D	S	A	L	Y	L
A104	A105	A106	A107	A108	A109	A110	A113
C	A	A	R	S	S	G	S
A114	A115	A116	A117	A118	A119	A120	A121
W	Q	L	I	F	G	S	G
A122	A123	A124	A125	A126	A127	A128
T	Q	L	T	V	M	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSQDRGDSAHTLY	None	14
CDRB2	YSYQML	None	6
CDRB1	LGHNA	None	5
CDRA3	AARSSGSWQLI	None	11
CDRA2	IFSNGE	None	6
CDRA1	DRNVDY	None	6

Orientation and docking angles:

Angle	Value
BC2	109.40°
BC1	71.92°
BA	-61.55°
AC2	77.83°
AC1	123.26°
dc	16.56Å
Docking angle	65.23°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
4ms8_DC	108.26°	71.77°	-62.08°	77.59°	124.79°	16.51Å	2.0
2nx5_ED	108.26°	71.73°	-60.30°	78.17°	124.77°	16.81Å	2.3
4mvb_DC	108.62°	71.71°	-62.21°	78.49°	125.19°	16.54Å	2.3
2nx5_JI	107.82°	71.33°	-61.50°	79.33°	124.52°	16.64Å	2.6
2q86_BA	109.01°	73.63°	-59.77°	78.68°	124.18°	16.58Å	2.8

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
2vxu_IM	110.96°	71.68°	-62.78°	78.60°	119.89°	16.17Å	4.0
1nmc_HL	110.09°	71.80°	-64.06°	80.19°	120.88°	16.16Å	4.3
1fbi_QP	113.29°	73.42°	-61.95°	78.25°	123.04°	15.83Å	4.3
2vxt_HL	112.53°	71.75°	-60.55°	78.20°	120.37°	16.05Å	4.4
3w14_PQ	112.54°	71.65°	-60.45°	80.80°	123.36°	16.03Å	4.5

D / C

TCR Details:

Item	Info
VB chain	D
VA chain	C
VB IMGT details	TRBV2/TRBJ2
VA IMGT details	TRAV7/TRAJ22
Species	mouse

Antigen Details:

Item	Info
Antigen Chain	N
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	VVGAVGVGK
Antigen Length	9

MHC details:

Item	Info
MHC Chain	L \| M
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*1101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B3	B4	B5	B6	B7	B8	B9	B10
K	I	I	Q	K	P	K	Y
B11	B12	B13	B14	B15	B16	B17	B18
L	V	A	V	T	G	S	E
B19	B20	B21	B22	B23	B24	B25	B26
K	I	L	I	C	E	Q	Y
B27	B28	B29	B37	B38	B39	B40	B41
L	G	H	N	A	M	Y	W
B42	B43	B44	B45	B46	B47	B48	B49
Y	R	Q	S	A	K	K	P
B50	B51	B52	B53	B54	B55	B56	B57
L	E	F	M	F	S	Y	S
B58	B63	B64	B65	B66	B67	B68	B69
Y	Q	M	L	M	D	N	Q
B70	B71	B72	B74	B75	B76	B77	B78
T	A	S	S	R	F	Q	P
B79	B80	B81	B83	B84	B85	B86	B87
Q	S	S	K	K	N	H	L
B88	B89	B90	B91	B92	B93	B94	B95
D	L	Q	I	T	A	L	K
B96	B97	B98	B99	B100	B101	B102	B103
P	D	D	S	A	T	Y	F
B104	B105	B106	B107	B108	B109	B110	B111
C	A	S	S	Q	D	R	G
B112A	B112	B113	B114	B115	B116	B117	B118
D	S	A	H	T	L	Y	F
B119	B120	B121	B122	B123	B124	B125	B126
G	S	G	T	R	L	T	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
Q	Q	K	V	Q	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
E	S	L	I	V	P	E	G
A17	A18	A19	A20	A21	A22	A23	A24
G	M	A	S	L	N	C	T
A25	A26	A27	A28	A29	A36	A37	A38
S	S	D	R	N	V	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	W	W	Y	R	Q	H	S
A47	A48	A49	A50	A51	A52	A53	A54
G	K	S	P	K	M	L	M
A55	A56	A57	A58	A63	A64	A65	A66
S	I	F	S	N	G	E	K
A67	A68	A74	A75	A76	A77	A78	A79
E	E	G	R	F	T	V	H
A80	A81	A82	A83	A84	A85	A86	A87
L	N	K	A	S	L	H	T
A88	A89	A90	A91	A92	A93	A94	A95
S	L	H	I	R	D	S	Q
A96	A97	A98	A99	A100	A101	A102	A103
P	S	D	S	A	L	Y	L
A104	A105	A106	A107	A108	A109	A110	A113
C	A	A	R	S	S	G	S
A114	A115	A116	A117	A118	A119	A120	A121
W	Q	L	I	F	G	S	G
A122	A123	A124	A125	A126	A127	A128
T	Q	L	T	V	M	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSQDRGDSAHTLY	None	14
CDRB2	YSYQML	None	6
CDRB1	LGHNA	None	5
CDRA3	AARSSGSWQLI	None	11
CDRA2	IFSNGE	None	6
CDRA1	DRNVDY	None	6

Orientation and docking angles:

Angle	Value
BC2	110.87°
BC1	73.17°
BA	-59.74°
AC2	78.20°
AC1	125.05°
dc	16.54Å
Docking angle	64.96°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
2q86_BA	109.01°	73.63°	-59.77°	78.68°	124.18°	16.58Å	2.2
8wte_DC	110.98°	73.31°	-59.85°	79.33°	122.99°	16.05Å	2.4
5ksa_DC	110.01°	73.34°	-58.57°	80.22°	126.34°	16.79Å	2.8
2nx5_ED	108.26°	71.73°	-60.30°	78.17°	124.77°	16.81Å	3.1
3c6l_FE	111.86°	72.92°	-59.42°	75.57°	123.91°	16.62Å	3.1

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
4jj5_BA	113.30°	75.08°	-58.94°	79.43°	123.53°	16.49Å	3.7
1fbi_QP	113.29°	73.42°	-61.95°	78.25°	123.04°	15.83Å	3.9
3w14_PQ	112.54°	71.65°	-60.45°	80.80°	123.36°	16.03Å	3.9
4osu_HL	113.36°	71.18°	-59.13°	79.75°	123.24°	15.69Å	4.1
4s1s_HL	113.28°	75.84°	-59.86°	79.98°	125.57°	15.71Å	4.1

F / E

TCR Details:

Item	Info
VB chain	F
VA chain	E
VB IMGT details	TRBV2/TRBJ2
VA IMGT details	TRAV7/TRAJ22
Species	mouse

Antigen Details:

Item	Info
Antigen Chain	Q
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	VVGAVGVGK
Antigen Length	9

MHC details:

Item	Info
MHC Chain	O \| P
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*1101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B3	B4	B5	B6	B7	B8	B9	B10
K	I	I	Q	K	P	K	Y
B11	B12	B13	B14	B15	B16	B17	B18
L	V	A	V	T	G	S	E
B19	B20	B21	B22	B23	B24	B25	B26
K	I	L	I	C	E	Q	Y
B27	B28	B29	B37	B38	B39	B40	B41
L	G	H	N	A	M	Y	W
B42	B43	B44	B45	B46	B47	B48	B49
Y	R	Q	S	A	K	K	P
B50	B51	B52	B53	B54	B55	B56	B57
L	E	F	M	F	S	Y	S
B58	B63	B64	B65	B66	B67	B68	B69
Y	Q	M	L	M	D	N	Q
B70	B71	B72	B74	B75	B76	B77	B78
T	A	S	S	R	F	Q	P
B79	B80	B81	B83	B84	B85	B86	B87
Q	S	S	K	K	N	H	L
B88	B89	B90	B91	B92	B93	B94	B95
D	L	Q	I	T	A	L	K
B96	B97	B98	B99	B100	B101	B102	B103
P	D	D	S	A	T	Y	F
B104	B105	B106	B107	B108	B109	B110	B111
C	A	S	S	Q	D	R	G
B112A	B112	B113	B114	B115	B116	B117	B118
D	S	A	H	T	L	Y	F
B119	B120	B121	B122	B123	B124	B125	B126
G	S	G	T	R	L	T	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
Q	Q	K	V	Q	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
E	S	L	I	V	P	E	G
A17	A18	A19	A20	A21	A22	A23	A24
G	M	A	S	L	N	C	T
A25	A26	A27	A28	A29	A36	A37	A38
S	S	D	R	N	V	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	W	W	Y	R	Q	H	S
A47	A48	A49	A50	A51	A52	A53	A54
G	K	S	P	K	M	L	M
A55	A56	A57	A58	A63	A64	A65	A66
S	I	F	S	N	G	E	K
A67	A68	A74	A75	A76	A77	A78	A79
E	E	G	R	F	T	V	H
A80	A81	A82	A83	A84	A85	A86	A87
L	N	K	A	S	L	H	T
A88	A89	A90	A91	A92	A93	A94	A95
S	L	H	I	R	D	S	Q
A96	A97	A98	A99	A100	A101	A102	A103
P	S	D	S	A	L	Y	L
A104	A105	A106	A107	A108	A109	A110	A113
C	A	A	R	S	S	G	S
A114	A115	A116	A117	A118	A119	A120	A121
W	Q	L	I	F	G	S	G
A122	A123	A124	A125	A126	A127	A128
T	Q	L	T	V	M	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSQDRGDSAHTLY	None	14
CDRB2	YSYQML	None	6
CDRB1	LGHNA	None	5
CDRA3	AARSSGSWQLI	None	11
CDRA2	IFSNGE	None	6
CDRA1	DRNVDY	None	6

Orientation and docking angles:

Angle	Value
BC2	108.86°
BC1	72.41°
BA	-59.28°
AC2	78.09°
AC1	123.49°
dc	16.57Å
Docking angle	63.52°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
2q86_BA	109.01°	73.63°	-59.77°	78.68°	124.18°	16.58Å	1.6
8dnt_IH	107.67°	72.60°	-59.28°	77.90°	124.75°	16.64Å	1.8
2nx5_ED	108.26°	71.73°	-60.30°	78.17°	124.77°	16.81Å	1.9
8dnt_PM	107.67°	71.80°	-59.96°	78.60°	124.64°	16.70Å	2.0
2ckb_DC	107.12°	72.74°	-58.19°	78.24°	122.91°	16.16Å	2.2

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
3w14_PQ	112.54°	71.65°	-60.45°	80.80°	123.36°	16.03Å	4.8
4osu_HL	113.36°	71.18°	-59.13°	79.75°	123.24°	15.69Å	5.0
2vxt_HL	112.53°	71.75°	-60.55°	78.20°	120.37°	16.05Å	5.1
1ghf_HL	110.63°	71.68°	-61.52°	81.98°	122.12°	16.05Å	5.1
1jfq_HL	112.09°	70.84°	-58.72°	81.15°	121.54°	16.08Å	5.2

H / G

TCR Details:

Item	Info
VB chain	H
VA chain	G
VB IMGT details	TRBV2/TRBJ2
VA IMGT details	TRAV7/TRAJ22
Species	mouse

Antigen Details:

Item	Info
Antigen Chain	T
Antigen Type	Peptide
Antigen Organism	HOMO SAPIENS
Antigen Sequence	VVGAVGVGK
Antigen Length	9

MHC details:

Item	Info
MHC Chain	R \| S
MHC Type	MH1
MHC Species	human
MHC IMGT details	HLA-A*1101

Numbered sequence

Chain type

Chain ID

FASTA/Annotation file

IMGT numbered sequence (Framework/CDR)

FASTA file

B3	B4	B5	B6	B7	B8	B9	B10
K	I	I	Q	K	P	K	Y
B11	B12	B13	B14	B15	B16	B17	B18
L	V	A	V	T	G	S	E
B19	B20	B21	B22	B23	B24	B25	B26
K	I	L	I	C	E	Q	Y
B27	B28	B29	B37	B38	B39	B40	B41
L	G	H	N	A	M	Y	W
B42	B43	B44	B45	B46	B47	B48	B49
Y	R	Q	S	A	K	K	P
B50	B51	B52	B53	B54	B55	B56	B57
L	E	F	M	F	S	Y	S
B58	B63	B64	B65	B66	B67	B68	B69
Y	Q	M	L	M	D	N	Q
B70	B71	B72	B74	B75	B76	B77	B78
T	A	S	S	R	F	Q	P
B79	B80	B81	B83	B84	B85	B86	B87
Q	S	S	K	K	N	H	L
B88	B89	B90	B91	B92	B93	B94	B95
D	L	Q	I	T	A	L	K
B96	B97	B98	B99	B100	B101	B102	B103
P	D	D	S	A	T	Y	F
B104	B105	B106	B107	B108	B109	B110	B111
C	A	S	S	Q	D	R	G
B112A	B112	B113	B114	B115	B116	B117	B118
D	S	A	H	T	L	Y	F
B119	B120	B121	B122	B123	B124	B125	B126
G	S	G	T	R	L	T	V
B127
L

FASTA file

A1	A2	A3	A4	A5	A6	A7	A8
Q	Q	K	V	Q	Q	S	P
A9	A10	A11	A12	A13	A14	A15	A16
E	S	L	I	V	P	E	G
A17	A18	A19	A20	A21	A22	A23	A24
G	M	A	S	L	N	C	T
A25	A26	A27	A28	A29	A36	A37	A38
S	S	D	R	N	V	D	Y
A39	A40	A41	A42	A43	A44	A45	A46
F	W	W	Y	R	Q	H	S
A47	A48	A49	A50	A51	A52	A53	A54
G	K	S	P	K	M	L	M
A55	A56	A57	A58	A63	A64	A65	A66
S	I	F	S	N	G	E	K
A67	A68	A74	A75	A76	A77	A78	A79
E	E	G	R	F	T	V	H
A80	A81	A82	A83	A84	A85	A86	A87
L	N	K	A	S	L	H	T
A88	A89	A90	A91	A92	A93	A94	A95
S	L	H	I	R	D	S	Q
A96	A97	A98	A99	A100	A101	A102	A103
P	S	D	S	A	L	Y	L
A104	A105	A106	A107	A108	A109	A110	A113
C	A	A	R	S	S	G	S
A114	A115	A116	A117	A118	A119	A120	A121
W	Q	L	I	F	G	S	G
A122	A123	A124	A125	A126	A127	A128
T	Q	L	T	V	M	P

CDR Sequences:

Loop	Sequence	Predicted canonical form	CDR Length
CDRB3	ASSQDRGDSAHTLY	None	14
CDRB2	YSYQML	None	6
CDRB1	LGHNA	None	5
CDRA3	AARSSGSWQLI	None	11
CDRA2	IFSNGE	None	6
CDRA1	DRNVDY	None	6

Orientation and docking angles:

Angle	Value
BC2	109.38°
BC1	72.89°
BA	-59.66°
AC2	78.25°
AC1	124.81°
dc	16.60Å
Docking angle	65.41°

TCRs with similar orientations:

TCR PDB	BC2	BC1	BA	AC2	AC1	dc	TRangle Distance
2q86_BA	109.01°	73.63°	-59.77°	78.68°	124.18°	16.58Å	1.1
2nx5_ED	108.26°	71.73°	-60.30°	78.17°	124.77°	16.81Å	1.7
8dnt_IH	107.67°	72.60°	-59.28°	77.90°	124.75°	16.64Å	1.8
8dnt_PM	107.67°	71.80°	-59.96°	78.60°	124.64°	16.70Å	2.1
7na5_ED	107.65°	72.03°	-60.43°	77.41°	125.33°	16.45Å	2.3

Antibodies with similar orientations:

Antibody PDB	HC2	HC1	HL	LC2	LC1	dc	ABangle Distance
3w14_PQ	112.54°	71.65°	-60.45°	80.80°	123.36°	16.03Å	4.6
4jj5_BA	113.30°	75.08°	-58.94°	79.43°	123.53°	16.49Å	4.9
1fbi_QP	113.29°	73.42°	-61.95°	78.25°	123.04°	15.83Å	5.0
4osu_HL	113.36°	71.18°	-59.13°	79.75°	123.24°	15.69Å	5.0
1ghf_HL	110.63°	71.68°	-61.52°	81.98°	122.12°	16.05Å	5.3

Available downloads

Additional links and files for download: see help for more details.

Item	Link
IMGT-numbered structure	Link
Non-annotated structure from the PDB	Link
Summary file for this TCR	Link
Link in the PDB	Link