Machine Learning based antibody Fv modelling
This web application is designed for small-scale structural modelling. If you would like to perform large-scale analyses, please contact: email@example.com
(*)NB: ABodyBuilder-ML uses the deep-learning approach to CDR loop modelling of ABlooper, replacing template-based modelling previously done with FREAD and Sphinx by the former ABodyBuilder pipeline. For a full description of the original ABodyBuilder pipeline, see this publication
To cite ABlooper, please refer to Abanades B, et al. ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation, Bioinformatics (2022)
IMPORTANT: ABodyBuilder-ML will become deprecated in the near future, as ABodyBuilder2 is now our main tool for antibody structure modelling, which will affect other tools such as TAP and Hu-mAb. To receive notifications for any of these updates, follow our Twitter account.
NB: Currently, ABodyBuilder-ML cannot be used to model VHH sequences as the protocol is designed to work with paired VH-VL sequences and the underlying machine-learning model has not been trained on VHH sequences. We are working on ways to accurately model VHH sequences and hope to make this feature available again soon.