Thera-SAbDab

UTOMILUMAB

>   Structural Summary
TherapeuticUtomilumab
TargetTNFRSF9
Heavy ChainEVQLVQSGAEVKKPGESLRISCKGSGYSFSTYWISWVRQMPGKGLEWMGKIYPGDSYTNYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARGYGIFDYWGQGTLVTVSS
Light ChainSYELTQPPSVSVSPGQTASITCSGDNIGDQYAHWYQQKPGQSPVLVIYQDKNRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCATYTGFGSLAVFGGGTKLTVL
100% seqID Fv Structure6a3w [Fvs: AB, DE, GH, JK], 6mi2 [Fvs: AB, DE]
99% seqID Fv StructureNone
95-98% seqID Fv StructureNone
>   Metadata
FormatWhole mAb
IsotypeG2
Highest Clinical Trial (August '23)Phase-II
Estimated Status (August '23)Active
Recorded Developmental TechnologyMorphoSys HuCAL Phage Display
INN Year Proposed2016
INN Year Recommended2017
Companies InvolvedDana-Farber Cancer Institute, Immatics US, Kite Pharma, Kyowa Hakko Kirin, M. D. Anderson Cancer Center, Pfizer
Conditions Approvedna
Conditions ActiveBreast cancer, Oropharyngeal cancer, Solid tumours, B-cell lymphoma, Diffuse large B cell lymphoma, Follicular lymphoma, Ovarian cancer
Conditions DiscontinuedNon-Hodgkin's lymphoma, Colorectal cancer
Notes

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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