SAbDab is a database containing all the antibody structures available in the PDB, annotated and presented in a consistent fashion. Each structure is annotated with a number of properties including experimental details, antibody nomenclature (e.g. heavy-light pairings), curated affinity data and sequence annotations. You can use the database to inspect individual structures, create and download datasets for analysis, search the database for structures with similar sequences to your query, monitor the known structural repetoire of antibodies, and much more. SAbDab-nano is a sub-database of SAbDab containing all nanobody structures available in the PDB, processed and annotated in the same manner as the structures deposited in SAbDab. SAbDab was built by the Oxford Protein Informatics Group (OPIG) under an open-innovation agreement. Our antibody prediction tools (such as modelling software, developability prediction software etc.) can be found at our SAbPred site. Please note that the data contained within SAbDab is available under a CC-BY 4.0 license.
See a summary of the data contained within SAbDab
Search for and view the antibody structures contained in the database.
Explore the complementarity determining regions (CDRs) of the antibodies in SAbDab.
Search for structures based on sequence identity.
Select antibodies based on the relative orientation of their VH and VL using ABangle.
Search specifically for the nanobody structures in the database.
Our database of Antibody- and Nanobody-derived Immunotherapeutic Structures: search by INN, metadata, or sequence.
Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]
SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]
Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]