Structure Viewer: 1mce

>   Structure details

Principles and Pitfalls in Designing Site Directed Peptide Ligands

PDB1mce
SpeciesHOMO SAPIENS
MethodX-RAY DIFFRACTION
Resolution2.7Å
Number of Fvs2
In complexTrue
Light chain typeLambda
Has constant regionTrue
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>   Fv information

This PDB has 2 Fv(s).

>   -/A
Fv Details
Heavy chain
Light chainA
Heavy subgroup
Light subgroupIGLV2
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
S A L T Q P P S A S G S L G Q S V T I S C T G T S S D V G G Y N Y V S W Y Q Q H A G K A P K V I I Y E V N K R P S G V P D R F S G S K S G N T A S L T V S G L Q A E D E A D Y Y C S S Y E G S D N F V F G T G T K V T V L

Antigen Details
Antigen chainsP
Antigen typepeptide
Antigen namepeptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-oh
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequenceXQFHPX

CDR Sequences (chothia definition)
CDRL1TGTSSDVGGYNYVS
CDRL2EVNKRPS
CDRL3SSYEGSDNFV

>   -/B
Fv Details
Heavy chain
Light chainB
Heavy subgroup
Light subgroupIGLV2
SpeciesHOMO SAPIENS
In complex?True
scFv?False
Has constant domain?True

Numbered Sequences (chothia)

Light chain

2 3 4 5 6 7 8 9 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 30A 30B 30C 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 95A 96 97 98 99 100 101 102 103 104 105 106 107
S A L T Q P P S A S G S L G Q S V T I S C T G T S S D V G G Y N Y V S W Y Q Q H A G K A P K V I I Y E V N K R P S G V P D R F S G S K S G N T A S L T V S G L Q A E D E A D Y Y C S S Y E G S D N F V F G T G T K V T V L

Antigen Details
Antigen chainsP
Antigen typepeptide
Antigen namepeptide n-acetyl-l-gln-d-phe-l-his-d-pro-b-ala-oh
Antigen speciesSYNTHETIC CONSTRUCT
Antigen sequenceXQFHPX

CDR Sequences (chothia definition)
CDRL1TGTSSDVGGYNYVS
CDRL2EVNKRPS
CDRL3SSYEGSDNFV

>   Downloads

Additional links and files for download: see help for more details.

Chothia-numbered structure Download
IMGT-numbered structure Download
Non-annotated structure from the PDB Download
Summary file for this antibody Download

Schneider, C., Raybould, M.I.J., Deane, C.M. (2022) SAbDab in the Age of Biotherapeutics: Updates including SAbDab-Nano, the Nanobody Structure Tracker. Nucleic Acids Res. 50(D1):D1368-D1372 [link]

SAbDab paper: Dunbar, J., Krawczyk, K. et al (2014). Nucleic Acids Res. 42. D1140-D1146 [link]

Thera-SAbDab paper: Raybould, M.I.J., Marks, C. et al (2019). Nucleic Acids Res. gkz827 [link]

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